cross-reaction


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cross-reaction

 [kros´re-ak-shun]
an interaction between an antibody and an antigen closely related to the antigen that specifically stimulated synthesis of the antibody.

cross-re·ac·tion

antibodies evoked by antigens with shared or similar idiotypic determinants may bind or cross-react with each other's respective antigens, even if their antigen-specificity is not identical.

cross-reaction

(krôs′rē-ăk′shən, krŏs′-)
n.
The reaction between an antigen and an antibody that was generated against a different but similar antigen.

cross′-re·act′ v.
cross′-re·ac′tive adj.
cross′-re·ac·tiv′i·ty n.

cross-reaction

Immunology A partial reaction or 'recognition' of an epitope by an antibody generated in response to another antigen

cross-re·ac·tion

(kraws'rē-ak'shŭn)
A specific reaction between an antiserum and an antigen complex other than the antigen complex that evoked the various specific antibodies of the antiserum. It is due to at least one antigenic determinant that is included among the determinants of the other complex.

cross-reaction

The association of an ANTIBODY with an ANTIGEN that differs from the antigen that first stimulated the production of the antibody. Cross reaction is unlikely unless there is close chemical similarity between the two antigens. Some diseases are believed to result because of antigenic similarities between certain body tissues and parts of infecting organisms, such as STREPTOCOCCI.

Cross-reaction

A reaction that occurs in blood testing when a disease agent reacts to the specific antibody for another disease agent. Cross-reactions are common in blood tests for fluke infections because the different species are closely related.

cross-reaction

a reaction which occurs when surface antigenic determinants on different molecules of quite different sources are identical, so that antibody directed against one antigen also reacts with another.
References in periodicals archive ?
Cross-reaction with luteinizing hormone R-core is responsible for the age-dependant increase of immunoreactive /3-core fragment of human chorionic gonadotropin in women with nonmalignant conditions.
Purified [beta]-LH-core did not cross-react in the free hCG[beta], free [alpha]-subunit, and intact hCG assays, but showed 100% cross-reaction in the LH and S-504 [beta]-core assays.
Specific cross-reactions in patients with heterophilic antibodies against the heterologous anti-analyte are increasingly observed, mainly with human anti-mouse antibodies (16).
The data compare very well with our findings, but we were able to considerably improve the test efficiency by inhibiting the major cross-reaction by using anti-B7 antiserum (Table 1).
For all the probes, the signal of cross-reaction was measurable only when 3 X [10.
Another potential problem is the cross-reaction with denatured LH.
Cross-reactions between pneumococci and other streptococci due to C polysaccharide and F antigen.
Some cross-reaction might occur because of the polyclonal nature of the detection antibody used.
In a sensitivity test involving all chikungunya serotypes and various alphaviruses, flaviviruses, and one phlebovirus, the RT-RPA assay identified all virus genotypes, with the only cross-reaction occurring with O'nyong'nyong virus.
When the researchers explored a potential cross-reaction between the HIV and HCV antibody tests, they found "no significant interference of the two tests," Liu noted.
It also has (1) high specificity and sensitivity, including innovative recombinant chimeric proteins (VIsE, DbpA, OspC), allowing detection of all main pathogenic Borrelia strains (sensu stricto, afzelii, garinii); (2) less rework and unnecessary confirmatory tests; and (3) low levels of cross-reaction (syphilis, other infectious diseases), for better patient management.
Currently used DNA-based techniques are either ineffective against excessively heat-treated samples, or a cross-reaction may occur between species-specific primer probes, which render detection in a processed meat mixture ineffective.