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cross tolerance

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cross tolerance
n.
Resistance to an effect or effects of a compound as a result of tolerance previously developed to a pharmacologically similar compound.

tolerance (tol´rns),
n the ability to endure the influence of a drug or poison, particularly acquired by continued use of the substance. See also resistance.
tolerance, acquired,
n tolerance that develops with successive doses of a drug. If it develops within a short span of time, such as 24 hours, it is called
tachyphylaxis. Slowly acquired tolerance is sometimes called
mithridatism.
tolerance, carbohydrate,
n the ability of the body to use carbohydrates. A decrease in tolerance is seen in diabetes mellitus, liver damage, and some infections and in the presence of hyperactivity of the adrenal cortex or pituitary gland.
tolerance, cross,
n tolerance to a number of drugs of similar mode of action or chemical structure.
tolerance, individual,
n tolerance characteristic of an individual.
tolerance, pseudo-,
n a state of apparent tolerance indicated due to failure of the drug to reach its usual receptor sites.
tolerance, species,
n tolerance characteristic of a species of animal.
tolerance, tissue,
n the ability of structures to endure environmental change without ill effect.
tolerance, upper intake level,
n the specified limit of a given substance that an individual may consume and not suffer detrimental or toxic effects.


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This phenomenon, known as cross tolerance (Koh, 2002), suggests that if muscles were treated by heat preconditioning, the induced HSPs might protect the muscle cells from eccentric exercise-induced muscle damage.
A few specific examples of reported cross tolerance include: salt stress inducing chilling tolerance, mechanical stress inducing chilling tolerance, water stress conferring chilling resistance, and heat stress inducing endurance to heavy metal toxicity, salt stress, water stress, and reducing chilling injury (Sabehat et al.
 
 
 
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