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cross tolerance

   Also found in: Dictionary/thesaurus, Encyclopedia, Hutchinson 0.10 sec.
cross tolerance
n.
Resistance to an effect or effects of a compound as a result of tolerance previously developed to a pharmacologically similar compound.

tolerance (tol´rns),
n the ability to endure the influence of a drug or poison, particularly acquired by continued use of the substance. See also resistance.
tolerance, acquired,
n tolerance that develops with successive doses of a drug. If it develops within a short span of time, such as 24 hours, it is called
tachyphylaxis. Slowly acquired tolerance is sometimes called
mithridatism.
tolerance, carbohydrate,
n the ability of the body to use carbohydrates. A decrease in tolerance is seen in diabetes mellitus, liver damage, and some infections and in the presence of hyperactivity of the adrenal cortex or pituitary gland.
tolerance, cross,
n tolerance to a number of drugs of similar mode of action or chemical structure.
tolerance, individual,
n tolerance characteristic of an individual.
tolerance, pseudo-,
n a state of apparent tolerance indicated due to failure of the drug to reach its usual receptor sites.
tolerance, species,
n tolerance characteristic of a species of animal.
tolerance, tissue,
n the ability of structures to endure environmental change without ill effect.
tolerance, upper intake level,
n the specified limit of a given substance that an individual may consume and not suffer detrimental or toxic effects.


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