cross resistance


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cross resistance

The ability of bacteria, viruses, or cancer cells to live and reproduce despite treatment with more than one drug. In cancer therapy, resistance to a wide range of unrelated drugs may occur after resistance to a single agent has developed.
Synonym: multidrug resistance; multiple drug resistance See: gene amplification
See also: resistance
References in periodicals archive ?
aureus strains develop a resistance against commonly used antibiotics, agar diffusion tests were carried out to check for cross resistance.
22] reported that bifenazate-resistant strain lacked cross resistance to many different chemical classes and modes of action of other acaricides This might be applied also on the results of the present study of chlortenapyr In South Korea, Lee et al.
Many isolates have cross resistance, judging from the findings of one study.
In light of the broad sensitivity of human ovarian tumor cell lines to ZD9331 and its lack of cross resistance to platinum based drugs, there is a strong rationale to expect this combination to be effective in treating advanced ovarian cancer patients," said Prof.
Our research team's detailed characterization of ITMN-191 provides important insight regarding how our compound is distinct from other experimental HCV protease inhibitors in development and reinforces our confidence that ITMN-191 has the potential to be a superior drug candidate with favorable cross resistance and potency profiles," said Dan Welch, President and CEO of InterMune.
Because keeping someone on a regimen allowing partial suppression, but unfortunately also allowing the virus to create more and more mutations, creates more and more cross resistance, potentially losing options you've been trying to save somebody for.
The use of irofulven in the treatment of recurrent glioma is of particular interest because its anti-tumor activity is independent of common drug-resistant mechanisms and it has no cross resistance with alkylating agents," adds Dr.