critical limb ischaemia


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critical limb ischaemia

; CLI advanced peripheral arterial disease (PAD); ischaemia so severe that limb viability is threatened (Table 1)
Table 1: Criteria used to define critical limb ischaemia
CriterionFeatureComment
1PainPersistent and regular rest pain persisting for > 2 weeks, requiring regular analgesia
Systolic pressuresAnkle < 50 mmHg; toe < 30 mmHg
2Tissue statusUlceration and/or gangrene of the foot/toes
Systolic pressuresAnkle < 50 mmHg; toe < 30 mmHg

Two criteria are used to define critical limb ischaemia: criterion 2 is especially applicable to patients, such as diabetics, with sensory neuropathy.

References in periodicals archive ?
stimulation: Data from a randomized trial on critical limb ischaemia.
It will also carry out phase one clinical trials in critical limb ischaemia, for which it will recruiting nine patients Both trials will use CTXCRYO, the cryopreserved variant of ReNeuron's CTX cell line which provides the drug product for both the stroke and critical limb ischaemia programmes.