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measurement of the clearance of endogenous creatinine, used for evaluating the glomerular filtration rate.
creatinine clearanceNephrology The ratio of the rate of creatinine excretion in urine to its concentration in serum, a value that reflects the body's ability to excrete creatinine; it is used to diagnose and monitor renal function
cre·at·i·nine clear·ance(krē-at'i-nin klēr'ăns)
A mathematical calculation of the total amount of creatinine excreted in the urine over a period of time, usually 24 hours to test renal function. The calculation is: creatinine clearance (mL/minute) = urine creatinine concentration (mL/dL) × volume of urine (mL/24 hour) ÷ plasma creatinine concentration (mg/dL) × 1440 minute/24 hour.
the act of clearing; it is a primary pharmacokinetic parameter which describes irreversible removal of a drug from the body by all processes and is made up of renal clearance and metabolic clearance.
the volume of the blood cleared of urea per minute by renal elimination.
see sulfobromophthalein clearance test.
see inulin clearance.
the time required for a drug to be eliminated after administration. Eliminated means to the point where it can no longer be detected. Of most importance in avoiding drug residues in food animals and charges of doping in sports animals.