creatinine clearance


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Related to creatinine clearance: Creatinine clearance test, Serum creatinine

cre·at·i·nine clear·ance

measurement of the clearance of endogenous creatinine, used for evaluating the glomerular filtration rate.

creatinine clearance

Nephrology The ratio of the rate of creatinine excretion in urine to its concentration in serum, a value that reflects the body's ability to excrete creatinine; it is used to diagnose and monitor renal function

cre·at·i·nine clear·ance

(krē-at'i-nin klēr'ăns)
A mathematical calculation of the total amount of creatinine excreted in the urine over a period of time, usually 24 hours to test renal function. The calculation is: creatinine clearance (mL/minute) = urine creatinine concentration (mL/dL) × volume of urine (mL/24 hour) ÷ plasma creatinine concentration (mg/dL) × 1440 minute/24 hour.

clearance

the act of clearing; it is a primary pharmacokinetic parameter which describes irreversible removal of a drug from the body by all processes and is made up of renal clearance and metabolic clearance.

blood-urea clearance
the volume of the blood cleared of urea per minute by renal elimination.
Bromsulphalein clearance
see sulfobromophthalein clearance test.
creatinine clearance
inulin clearance
see inulin clearance.
clearance time
the time required for a drug to be eliminated after administration. Eliminated means to the point where it can no longer be detected. Of most importance in avoiding drug residues in food animals and charges of doping in sports animals.
urea clearance
blood-urea clearance.
References in periodicals archive ?
Briefly, we computed the score from 7 independent variables weighted to their respective odds ratio (OR) [age >65 years (2 points), admission heart failure (3 points), baseline left ventricular ejection fraction (LVEF) <40% (4 points), anemia (2 points, defined as a baseline hematocrit <39% for men and <36% for women), creatinine clearance <60 mL/min (3 points), triple-vessel disease (2 points), and postprocedural TIMI (Thrombolysis in Myocardial Infarction) flow grade <III (2 points)].
1-21 Creatinine clearance (mL/min) (e) 103 100 83 116 20-239 Urinary albumin ([micro]g/min) (f) 3.
By contrast, the present similar community-based study of elderly subjects finds that cystatin C was no better than creatinine or creatinine clearance as a predictor for incident CHD or CVD.
Three hour endogenous creatinine clearance (Ccr) as a test of glomerular filtration (GFR) in normal subjects and patients with chronic renal failure.
Because there were no associations between cadmium and GFR or creatinine clearance (for urinary cadmium) in never-smokers, we tested whether there was confounding through a non-cadmium-dependent effect of smoking by including pack-years in the multiple regression models.
Although a creatinine clearance can be measured from the collected samples, it is well known that creatinine clearance may significantly overestimate true GFR.
Study, year, country Outcomes of origin (Reference) Merten et al, 2004, An incremental rise in serum USA (9) creatinine concentration >25% above baseline, number of patients required dialysis, change in serum creatinine concentration, potassium concentration, urinary pH and creatinine clearance from the baseline.
Urine creatinine was measured in spot samples (for adjustment of NAG and RBP) and in the 4-hr sample after DMSA (for determination of measured creatinine clearance and adjustment of DMSA-chelatable lead levels), using a modification of the Sigma kit (Sigma Chemical Company, St.
Consistent with its effect on creatinine clearance, CD-NP elicited a statistically significant reduction of cystatin C, another biomarker of renal function.
The CG equation is still commonly used for estimating creatinine clearance as an indicator of GFR and was therefore included in the analysis.
Many studies have reported impaired renal function and kidney disease at high levels of lead exposure, as estimated mainly through concentrations of serum creatinine (SCr) and rates of creatinine clearance from the body.

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