creatine kinase isoenzymes

cre·a·tine ki·nase i·so·en·zymes

the isoenzymes of creatine kinase. Creatine kinase is a dimer with M (muscle) and/or B (brain) subunits; it exists in three isoenzyme forms: CK-MM, the predominant form, found primarily in skeletal muscle; CK-MB, found in cardiac muscle, tongue, diaphragm, and in small amounts in skeletal muscle; and CK-BB found in the brain, smooth muscle, thyroid, lungs, and prostate. Elevations detected by electrophoresis or other methodologies can be used to help in the differential diagnosis of a variety of disease states, with CK-MB elevations as an important marker following myocardial infarctions, elevations in CK-MM an indicator of muscle disease, and increases in CK-BB an occasional finding following brain infarcts, bowel infarcts, or in the presence of certain malignancies.
References in periodicals archive ?
Role of creatine kinase isoenzymes on muscular and cardiorespiratory endurance.
Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the phosphocreatine circuit for cellular energy homeostasis.
Rapid separation of plasma creatine kinase isoenzymes by batch adsorption on glass beads.
Creatine kinase isoenzymes in extracts of various human skeletal muscles.
Stability of macro creatine kinases and creatine kinase isoenzymes compared: heat inactivation test for determination of thermostable creatine kinases.
Differential diagnosis of patients with abnormal serum creatine kinase isoenzymes.
Separation of Tissue and Serum Creatine Kinase Isoenzymes by Ion-Exchange Column Chromatography Donald W.
Evaluation and comparison of immunoinhibition and immunoprecipitation methods for differentiating MB from BB and macro forms of creatine kinase isoenzymes in patients and healthy individuals.
Canine myocardial creatine kinase isoenzymes after chronic coronary artery occlusion.
Evaluation and comparison of immuno-inhibition and immunoprecipitation methods for differentiating MB from BB and macro forms of creatine kinase isoenzymes in patients and healthy individuals.