covalent modification

co·va·lent mod·i·fi·ca·tion

alteration in the structure of a macromolecule by enzymatic means, resulting in a change in the properties of that macromolecule; frequently, this type of modification is physiologically relevant.
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Covalent modification of histone proteins through acetylation and deacetylation affects chromatin structure and regulates gene expression.
Quinone toxicity has been found to involve two primary initiating mechanisms: a) a 1,4-Michael addition reaction leading to covalent modification of cellular targets (Endo et al.
As a simple reformulation, Arestat™ can be readily incorporated into standard manufacturing practice, without covalent modification of the biologic and using excipients approved for the route of delivery.
Nothing is impossible," cyclic AMP was heard to say; "My dear hepatocytes there is no cause for dismay; By simple covalent modification these enzymes can be tamed; They can be made to dance to our tunes or temporarily maimed.
This involves looking at patterns of DNA methylation and covalent modification of histone tails, which Dr.
om the environment; and (ii) screening said exposed libraries utilizing an assay requiring a binding event or the covalent modification of a target, and a fluorescence activated cell sorter to identify positive clones.
Application of protein covalent modification to studying the structure and function of HIV-1 integrase and its inhibitors
com)-- Cellular phosphorylation is a reversible, covalent modification of a protein or lipid that results in the modification of the activity of the phosphorylated molecule by inducing small conformational changes within the molecule.
Phoenix Pharmacologic's technology enhances the action of its drugs through covalent modification with polyethylene glycol.
o Design: proprietary informatics to uniquely identify sites amenable to selective covalent modification and target silencing;
The ability to label a protein using two different probes, and to quantify the labeling over a large dynamic range, provides us with a powerful tool with which to examine the role of covalent modification in regulating protein activity and function.
Furthermore, it is presently estimated that over 10% of cellular proteins are subject to covalent modification via phosphorylation.