coumarin

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coumarin

 [koo´mah-rin]
1. a principle extracted from the tonka bean, from which several anticoagulants are derived that inhibit hepatic synthesis of vitamin K–dependent coagulation factors.
2. any of these derivatives.

cou·ma·rin

(kū'mă-rin),
1. A general descriptive term applied to anticoagulants and other drugs derived from dicumarol, a component of the Tonka bean.
2. A fragrant neutral principle obtained from the Tonka bean, Dypterix odorata, and made synthetically from salicylic aldehyde; it is used to disguise unpleasant odors.
[coumarou, native name of Tonka bean]

coumarin

/cou·ma·rin/ (koo´mah-rin)
1. a principle extracted from the tonka bean; it contains a factor, dicumarol, that inhibits hepatic synthesis of vitamin K–dependent coagulation factors, and a number of its derivatives are used as anticoagulants in treating disorders characterized by excessive clotting.
2. any of these derivatives or any synthetic compound with similar activity.

coumarin

(ko͞o′mər-ĭn)
n.
A fragrant crystalline compound, C9H6O2, present in tonka beans and produced synthetically for use as a fragrance. Coumarin has been banned as a food additive in the United States because it can be toxic in large amounts.

cou′ma·ric (-mər-ĭk) adj.

coumarin

[ko̅o̅′mərin]
a class of orally active anticoagulant agents with warfarin as its prototype.
indications It is prescribed for prophylaxis and treatment of thrombosis and embolism.
contraindications Known hypersensitivity to the drug prohibits its use. It is not prescribed to patients who are at risk for hemorrhage or who are pregnant.
adverse effects The most serious adverse reaction is hemorrhage. Many other drugs interact with this drug to increase or decrease its effect.

cou·ma·rin

(kū'mă-rin)
Fragrant neutral principle obtained from the Tonka bean, Dypterix odorata, and also made synthetically from salicylic aldehyde; used to disguise unpleasant odors.

coumarin,

n C9H6O, derived from a variety of sources, including tonka bean and sweet clover; may also be artificially manufactured.
Enlarge picture
Coumarin.

cou·ma·rin

(kū'mă-rin)
A general descriptive term applied to anticoagulants and other drugs derived from dicumarol.

coumarin

1. a principle extracted from the tonka bean, from which several anticoagulants are derived, that inhibits hepatic synthesis of vitamin K-dependent coagulation factors.
2. any of these derivatives.
3. see also dicoumarol.
References in periodicals archive ?
Melissa extracts contain a large amount of detectable phytochemicals, including phenolic acids (rosmarinic acid, coumaric acid, caffeic acid, protocatechuic acid, ferulic acid, chlorogenic acid), flavonoids (quercetin, luteolin, apigenin, and their glucosides), sesquiterpenes ([beta]-caryophyllene and germacrene), monoterpenes ([beta]-pinene) and triterpenes (Chung et al.
Compounds used were salicylic acid, cinnamic acid, coumaric acid, caffeic acid, and untreated control.
1 Standards Coumaric acid Catechin Cafeic acid Retention time (minute) 38.
In spite of the presence of gallic, syringic, chlorogenic, vanillic, caffeic, ferulic, and coumaric acids in Chenopodium album, only chlorogenic acid was identified as a principle allelochemical (Mallik et al.
Flavonols, coumaric acid derivatives and stilbenes were expressed as quercetin, coumaric acid and transresveratrol equivalents, respectively.
Phytochemicals such as ferulic acid, chlorogenic acid, caffeic acid, coumaric acid, cinnamic acid, eugenol, berberine have shown synergistic interaction with commercial oral antidiabetic drugs when they are tested in two different cell lines at basal level (Prabhakar and Doble 2009, 2011 a,b,c).
Among phenolic compounds pinocembrin, chrysin and galangin were determined to be present; and 9-octadecanoic acid, palmitic acid, decanoic acid, coumaric acid and cinnamic acids were demonstrated to exist as organic acids (Table 2).