cosyntropin


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cosyntropin

 [ko″sin-tro´pin]
a synthetic corticotropin used in the screening of adrenal insufficiency on the basis of plasma cortisol response after intramuscular or intravenous injection.

co·syn·tro·pin

(kō-sin-trō'pin),
α1-24- or β1-24-Corticotropin; a synthetic corticotrophic agent, comprising the first 24 amino acyl residues of human ACTH, which sequence is found in several other species and which retains the full biologic activity of the complete ACTH; the remaining 15 residues differ among species and confer specific immunologic properties.

cosyntropin

/co·syn·tro·pin/ (ko-sin-tro´pin) a synthetic polypeptide identical with a portion of corticotropin, having its corticotropic activity but not its allergenicity; used in the screening of adrenal insufficiency on the basis of plasma cortisol response.

cosyntropin

(kō′sĭn-trō′pĭn)
n.
A synthetic corticotropin.

cosyntropin

[kō`sintrop′in]
a synthetic form of adrenocorticotropic hormone that is used in the diagnosis and treatment of adrenal hypofunction disorders such as Addison's disease to determine if the disorder is primary (adrenal dysfunction) or secondary (hypothalamic-pituitary axis dysfunction).

cosyntropin

a synthetic corticotropin used in the screening of adrenal functional capacity on the basis of plasma cortisol response after intramuscular or intravenous injection. Called also tetracosactrin.
References in periodicals archive ?
Cosyntropin and sumatriptan did not relieve her headache or neck pain.
Both oCRF and cosyntropin produce lower ACTH and/or cortisol responses in alcohol-dependent men compared with nonalcoholic men (Adinoff et al.
Adrenal insufficiency was excluded with a cosyntropin stimulation test, with a normal increase in serum cortisol from a baseline of 13 [micro]g/dL to 24 [micro]g/dL.
Etomidate, even in bolus doses, has been known to reversibly suppress adrenal cortical function causing a relative AI, (11) but this has not been considered sufficiently clinically significant to avoid use of the drug in emergency care because the serum cortisol levels remained at normal limits and the cosyntropin stimulation test results returned to normal at or soon after 24 hours.
1 [micro]g/dl and delta cortisol after the administration of 250 [micro]g of cosyntropin was 9.
A work-up for infection, malignancy, and rheumatologic conditions was negative, and primary adrenal insufficiency was ruled out based on the findings of a cosyntropin stimulation test.
Pituitary-adrenal axis needs be evaluated with dynamic tests, either insulin tolerance test or a 250 [micro]g cosyntropin stimulation test according to the patient's status.
All patients underwent 60-minute cosyntropin testing; 47 percent were considered to be cosyntropin nonresponders.
The researchers found that all patients showed an adequate adrenal response to cosyntropin before and after budesonide therapy.
A cosyntropin stimulation test, T4, reverse T3 levels, prolactin, thyroid antibodies, and transglutaminase IgA and IgG levels were all within normal limits.
A short cosyntropin test produced a peak cortisol concentration of 34.
In search of nascent Addison disease, cortisol following cosyntropin injection and renin should be measured on a yearly basis.