cosyntropin


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cosyntropin

 [ko″sin-tro´pin]
a synthetic corticotropin used in the screening of adrenal insufficiency on the basis of plasma cortisol response after intramuscular or intravenous injection.

co·syn·tro·pin

(kō-sin-trō'pin),
α1-24- or β1-24-Corticotropin; a synthetic corticotrophic agent, comprising the first 24 amino acyl residues of human ACTH, which sequence is found in several other species and which retains the full biologic activity of the complete ACTH; the remaining 15 residues differ among species and confer specific immunologic properties.

cosyntropin

/co·syn·tro·pin/ (ko-sin-tro´pin) a synthetic polypeptide identical with a portion of corticotropin, having its corticotropic activity but not its allergenicity; used in the screening of adrenal insufficiency on the basis of plasma cortisol response.

cosyntropin

(kō′sĭn-trō′pĭn)
n.
A synthetic corticotropin.

cosyntropin

[kō`sintrop′in]
a synthetic form of adrenocorticotropic hormone that is used in the diagnosis and treatment of adrenal hypofunction disorders such as Addison's disease to determine if the disorder is primary (adrenal dysfunction) or secondary (hypothalamic-pituitary axis dysfunction).

cosyntropin

a synthetic corticotropin used in the screening of adrenal functional capacity on the basis of plasma cortisol response after intramuscular or intravenous injection. Called also tetracosactrin.
References in periodicals archive ?
A screening serum 17-OHP level of > 6 nmol/L was an indication to obtain a complete adrenocortical profile and to perform a highdose (250 [micro]g) cosyntropin stimulation test (HDSST).
under which Depomed will acquire from SlAaAaAeA n rights to market t specialty drug, cosyntropin (Synthetic ACTH Depot) in the United States and divest its Lazanda (fentanyl) nasal spray CII to SlAaAaAeA n, the compa said.
under which Depomed will acquire from SlAaAaAeAaAaAeAeA n rights to market specialty drug, cosyntropin (Synthetic ACTH Depot) in the United States and divest its Lazanda (fentanyl) nasal spray CII to SlAaAaAeAaAaAeAeA n, the com said.
Food and Drug Administration (FDA) has granted orphan drug designation to MNK-1411, a long-acting formulation containing cosyntropin acetate under investigation for the treatment of Duchenne muscular dystrophy (DMD).
Continuous cosyntropin stimulation (50 [micro]g/h) was used during AVS procedures at Nijmegen, whereas procedures at the 2 other centers were performed without cosyntropin.
Adrenal insufficiency is diagnosed with an early morning serum cortisol test and a cosyntropin stimulation test.
Moreover they also showed that etomidate was associated with reduced cosyntropin stimulation response test after 3 hours of induction but it was back to normal after 12 hours of induction.
A cosyntropin stimulation test was negative, showing that adrenal insufficiency did not cause his orthostatic hypotension.
Most investigators concur that a lateralization index of 4 or higher during cosyntropin stimulation ([greater than or equal to] 2 for unstimulated adrenal vein sampling) is indicative of unilateral aldosterone production and favors the diagnosis of aldosterone-producing adenoma, whereas a lateralization index lower than 4 is more suggestive of bilateral aldosterone production involving bilateral adrenal hyperplasia.
TSH, free thyroxin), Serum prolactin level, Total and free testosterone levels, Free androgen index, Serum HCG level, Cosyntropin stimulation test serum 17-hydroxyprogesterone (17-OHPG) level, Urinary free cortisol (UFC) and creatinine levels, Low-dose dexamethasone suppression test, Serum insulin like growth factor (IGF)1 level Other tests used in the evaluation of PCOS include the following on testing, Glucose level and Insulin level.
In search of nascent Addison disease, cortisol following cosyntropin injection and renin should be measured on a yearly basis.