mice at baseline and suggested that low levels of alveolar macrophage costimulatory molecule
expression are maintained at least in part by endogenous IL-10 activity.
Study title: "Comparing the Overall Survival of Metastatic Castration-Resistant Prostate Cancer Patients Treated with Docetaxel, a Vaccine Admixed with one Costimulatory Molecule
, and a Vaccine with Three Costimulatory Molecules
Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule
CD40 ligand: An open-label trial.
IDEC-114 is a monoclonal antibody that targets CD80, an immune costimulatory molecule
that is routinely expressed at low levels on the surface of follicular lymphomas and other lymphoid malignancies.
CD54 is a costimulatory molecule
which serves as a marker for APCs.
However, they do not have the ability to produce the costimulatory molecules
needed for an immunogenic response in T cells.
5] exposure are associated with up-regulated blood monocyte surface expression of costimulatory molecules
that promote an APC phenotype.
A number of costimulatory molecules
are present on the T-cell membrane, which may have stimulatory or inhibitory effects on T lymphocytes.
PROSTVAC(TM) is an 'off-the-shelf' viral vector-based immunotherapy, utilizing pox virus vectors that express PSA and three T cell costimulatory molecules
are administered subcutaneously.
Abnormal differentiation of dendritic cells gives rise to accumulation of immature DCs with dysregulated expression of costimulatory molecules
More recently, the study team tried PSA-targeted fowlpox and vaccinia vaccines in combination with costimulatory molecules
in 15 men with metastatic prostate cancer.
IL-10 down-regulates costimulatory molecules
on Mycobacterium tuberculosis-pulsed macrophages and impairs the lytic activity of CD4 and CD8 CTL in tuberculosis patients.