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cosmid

   Also found in: Dictionary/thesaurus, Wikipedia, Hutchinson 0.01 sec.
cosmid
a class of plasmid-based vectors carrying the bacteriophage λ cos sequences required for packaging of DNA into phage particles. Used for cloning large DNA fragments (up to 45 kilobases). Recombinant molecules constructed using cosmids are incorporated into bacteriophage using in vitro packaging extracts and introduced with high efficiency into Escherichia coli.


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Sequencing and Annotation of pO113 The complete nucleotide sequence of pO113 from EH41 was determined from a series of overlapping 30-40 kb fragments cloned into the Copy Control pCC1FOS cosmid vector (Epicentre, Madison, WI, USA) and propagated in E.
An acceleration of this disorder occurs in transgenic mice expressing human and mouse Alzheimer amyloid precursor proteins produced using a hamster prion protein gene-derived cosmid vector that confers position-independent, copy number-dependent expression.
The genes are found on a single region of the LB400 chromosome and were originally cloned into a broad host-range cosmid (pGEM410).
 
 
 
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