As expected, cosegregation
analysis of the mutations revealed that each parent was a carrier of one alteration.
Currently, such supporting evidence includes detecting a recurring de novo mutation in a gene with a deleterious effect on the encoded protein in similarly affected patients, showing cosegregation
in family members, and/or providing compelling evidence of the underlying biology and mechanism.
All SGI ROTAV strains were associated with the P or P genotype, and all SGII ROTAV strains were associated with P, demonstrating a gene-dependent cosegregation
Unfortunately, no relatives were available to perform cosegregation
Familial predisposition and cosegregation
analysis of adult obstructive sleep apnea and the sudden infant death syndrome.
Iodide organification defects resulting from cosegregation
of mutated and null thyroid peroxidase alleles.
Brassicaceae) analysed by a cosegregation
of phenotypic characters (QTL) and molecular markers.
The investigators noticed cosegregation
of dyslexia, defined by oral reading ability at least two years below expected grade level, and a cytogenetic polymorphism at the top of the acrocentric chromosome 15 in eight families selected on the basis of apparent autosomal dominant transmission of the disorder.
of a novel Bartonella species with Borrelia burgdorferi and Babesia microti in Peromyscus leucopus.
Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation
with severe hyperlipidemia.
henselae DNA has been amplified, and that serologic and molecular evidence suggests cosegregation
of Bartonella spp.
In two families, cosegregation
with the disease could not be assessed because of a lack of available DNA samples.