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a glucocorticoid with significant mineralocorticoid activity, isolated from the adrenal cortex, largely inactive in humans until it is converted to hydrocortisone (cortisol). Cortisone, as the acetate ester, is used as an antiinflammatory and immunosuppressant and for replacement therapy in adrenocortical insufficiency; administered orally or by intramuscular injection.
cortisone(kōr'ti-sōn), Avoid using this word as a synonym of adrenocortical steroid.
17-hydroxy-11-dehydrocorticosterone, a biologically inactive adrenal corticosteroid produced by the reversible 11-hydroxylation of cortisol (17-hydroxycorticosterone). It was the first glucocorticoid to be used in therapy (1949). Like the endogenous substance, natural and synthetic cortisone administered as a drug exerts no effect until converted to cortisol.
Synonym(s): Wintersteiner compound E
cortisone/cor·ti·sone/ (-sōn) a natural glucocorticoid that is metabolically convertible to cortisol; the acetate ester is used as an antiinflammatory and immunosuppressant and for replacement therapy in adrenocortical insufficiency.
A naturally occurring corticosteroid, C21H28O5, that is converted in the body to cortisol. It is used in synthetic form as a drug, especially to treat adrenal insufficiency, certain allergies, and inflammation, as from rheumatoid arthritis.
a synthetic glucocorticoid.
indication It is prescribed for adrenocortical insufficiency inflammation.
contraindications Fungal infections or known hypersensitivity to this drug prohibits its systemic use. Viral or fungal infections of the skin, impaired circulation, or known hypersensitivity to this drug prohibits its topical use.
adverse effects Among the more serious adverse reactions to the systemic administration of the drug are GI, endocrine, neurological, fluid, and electrolyte disturbances, so the drug must be used with caution when there are pre-existing conditions. Skin reactions may result from topical administration. Therapy lasting longer than a few days can lead to hypothalamic-pituitary-adrenal suppression.
cortisone(1) An older, “short form” for corticosterone.
(2) Cortisone (17 alpha-,21-dihydroxy-4-pregnene-3,11,20-trione).
cortisoneA glucocorticoid derived from cortisol, the term cortisone may be used generically to refer to all synthetic glucocorticoids
A glucocorticoid not normally secreted in significant quantities by the human cortex of the suprarenal gland. It exhibits no biologic activity until converted to hydrocortisone (cortisol); it acts on carbohydrate metabolism and influences the nutrition and growth of connective (collagenous) tissues.
cortisoneThe first corticosteroid produced for treatment purposes. It is converted to hydrocortisone in the liver. It was used to treat rheumatoid arthritis, severe allergies, adrenal failure and other conditions but has been largely replaced by more powerful synthetic steroids. A brand name is Cortisyl.
cortisonea GLUCOCORTICOID hormone secreted by the adrenal cortex, whose function is to combat stress. It causes shrinkage of lymph nodes and lowers the white blood cell count, reduces inflammation, promotes healing and stimulates GLUCONEOGENESIS. Cortisone controls its own production, which is triggered by the ADRENOCORTICOTROPIC HORMONE in a negative FEEDBACK MECHANISM.
Glucocorticoid produced by the adrenal cortex in response to stress. Cortisone is a steroid and has anti-inflammatory and immunosuppressive properties.
cor·ti·sone(kōr'ti-sōn) Avoid using this word as a synonym of adrenocortical steroid.
Biologically inactive adrenal corticosteroid produced by the reversible 11-hydroxylation of cortisol (17-hydroxycorticosterone).