corticotropin-releasing factor (korˈ·ti·kō·trōˑ·pin-rē·lēˑ·sing fakˑ·ter),
n substance secreted by the hypo-thalamus that triggers the pituitary-adrenal axis. The increased release of this substance plays a significant role in immunosuppression and has other secondary effects. Also called
CRF.
CRF.
)
Corticotropin-releasing factor.
corticotropin
1. adrenocorticotropic hormone. See also acth.
2. a pharmaceutical preparation derived from the anterior pituitary of mammals and used to stimulate adrenal cortical activity in various conditions, such as allergy, hypersensitivity and rheumatoid arthritis. It has also been used experimentally in a large number of disorders.
corticotropin-like intermediary peptide
a polypeptide hormone of the intermediate pituitary; stimulates insulin release from the pancreas.
corticotropin-releasing factor
secreted by the hypothalamus and conveyed by local circulation to the corticotrophs in the pituitary which are then stimulated to produce ACTH. Called also corticotropin-releasing hormone (CRF).
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