corticotropin


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Related to corticotropin: corticotropin releasing factor

corticotropin

 [kor″tĭ-ko-tro´pin]
1. a hormone secreted by the anterior lobe of the pituitary gland that stimulates the cortex of the adrenal gland to secrete its hormones, including corticosterone. If production of corticotropin falls below normal, the adrenal cortex decreases in size, and production of the cortical hormones declines.
2. a pharmaceutical preparation of animal-derived corticotropin, administered intravenously for diagnostic testing of adrenocortical function and subcutaneously or intramuscularly, in a slowly absorbed gel form (repository corticotropin), as an anticonvulsant for treating infantile spasms. Called also adrenocorticotropic hormone (ACTH), adrenocorticotropin, and corticotrophin.

a·dre·no·cor·ti·co·tro·pic hor·mone (ACTH),

the hormone of the anterior lobe of the hypophysis that governs the nutrition and growth of the adrenal cortex, stimulates it to functional activity, and shows extraadrenal adipokinetic activity; it is a polypeptide containing 39 amino acids, but exact structure varies from one species to another; sometimes prefixed by α to distinguish it from β-corticotropin. The first 13 amino acids at the N-terminal region are identical to α-melanotropin.

corticotropin

/cor·ti·co·tro·pin/ (-tro´pin)
1. a hormone secreted by the adenohypophysis, having a stimulating effect on the adrenal cortex.
2. a preparation of the hormone derived from animals, used for diagnostic testing of adrenocortical function and as an anticonvulsant in infantile spasms.

corticotropin

(kôr′tĭ-kō-trō′pən) also

corticotrophin

(-trō′fĭn)
n.
See ACTH.

corticotropin

corticotropin

 ACTH, see there.

ad·re·no·cor·ti·co·tro·pic hor·mone

(ACTH) (ă-drē'nō-kōr'ti-kō-trō'pik hōr'mōn)
The hormone of the anterior lobe of the hypophysis that governs the nutrition and growth of the cortex of the suprarenal gland and stimulates it to functional activity; also possesses extraadrenal adipokinetic activity.
Synonym(s): adrenotropin, corticotropin.

adrenocorticotropic, adrenocorticotrophic hormone (ACTH) or corticotropin

a small, proteinaceous hormone secreted by the anterior lobe of the PITUITARY. It controls the secretion of other hormones of the cortex of the ADRENAL GLAND.

corticotropin (kôr´tikōtrō´pin),

n a purified preparation of adrenocorticotropic hormone derived from the pituitary gland of animals. See also ACTH.

corticotropin

1. adrenocorticotropic hormone. See also acth.
2. a pharmaceutical preparation derived from the anterior pituitary of mammals and used to stimulate adrenal cortical activity in various conditions, such as allergy, hypersensitivity and rheumatoid arthritis. It has also been used experimentally in a large number of disorders.

corticotropin-like intermediary peptide
a polypeptide hormone of the intermediate pituitary; stimulates insulin release from the pancreas.
corticotropin-releasing factor
secreted by the hypothalamus and conveyed by local circulation to the corticotrophs in the pituitary which are then stimulated to produce ACTH. Called also corticotropin-releasing hormone (CRF).
References in periodicals archive ?
Comparison of basal neuropeptide Y and corticotropin releasing factor levels between the high ethanol drinking C57BL/6J and low ethanol drinking DBA/2J inbred mouse strains.
A role for corticotropin releasing factor (CRF) in ethanol consumption, sensitivity, and reward as revealed by CRF-deficient mice.
Corticotropin gel is a purified corticotropin (ACTH) in a sterile solution of gelatin for prolonged activity.
ANI") (NASDAQ: ANIP) today announced that it has agreed to acquire the NDAs for purified corticotropin gel and corticotropin-zinc hydroxide from Merck (known as MSD outside of the United States and Canada) for $75 million in cash and a percentage of future net sales.
Acthar Gel is repository corticotropin injection currently approved by the FDA for 19 indications in four key, hard-to-treat areas: acute exacerbations of multiple sclerosis; proteinuria in ideopathic types of nephrotic syndrome; infantile spasms in children under 2 years old; and rheumatology-related conditions such as polymyositis and dermatomyositis.
Acthar([R]) Gel (repository corticotropin injection) for the treatment of infantile spasms.
Acthar([R]) Gel (repository corticotropin injection), an injectable drug indicated for the treatment of exacerbations associated with Multiple Sclerosis and Doral([R]) (quazepam) that is indicated for the treatment of insomnia, characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings.
Acthar Gel (repository corticotropin injection) for the following rheumatology-related FDA-approved indications on the label for Acthar:
Acthar[R] Gel (repository corticotropin injection), an injectable drug that is approved by the FDA for the treatment of 19 indications.
Acthar([R]) Gel (repository corticotropin injection), an injectable drug indicated for the treatment of exacerbations associated with multiple sclerosis and Doral([R]) (quazepam), that is indicated for the treatment of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings.
Acthar([R]) Gel (repository corticotropin injection) will be presented at the annual meeting of the American Epilepsy Society (AES) December 1-5 in San Diego, California.
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