adenomas (~10% of pituitary tumors) stain immunopositive for ACTH.
In our patient, inappropriate secretion of ACTH from a corticotroph
adenoma or hyperplasia in a brief period may be described by inappropriate replacement with synthetic glucocorticoid.
Histological and immunohistochemical findings led to identification of corticotroph
adenocarcinoma in the pituitary gland.
Proliferation of lactosomatotroph GH3 and somatotroph MtT/S rat pituitary cells as well as of corticotroph
AtT20 mouse pituitary cells was inhibited by curcumin in monolayer cell culture and in colony formation assay in soft agar.
It also acts on other central and peripheral receptors and exhibits other actions, including stimulation of lactotroph and corticotroph
secretion; it also influences gastroenteropancreatic functions and has orexigenic, metabolic, cardiovascular, and antiproliferative effects (60-62).
Invasion is characteristic of thyrotroph adenomas, silent corticotroph
adenomas, and the unusual plurihormonal silent subtype 3 adenomas.
DDAVP stimulates ACTH release via the specific corticotroph
AVP receptor (1,6).
Tumor Progression after Adrenalectomy in Cushing's Disease: A Reappraisal of Nelson's Syndrome.
PPAR-gamma ligands inhibit in vitro and in vivo corticotroph
tumor growth by increasing the apoptotic pituitary corticotroph
The hypothalamus produces corticotropic hormone, which stimulates corticotrophs
to release ACTH, which then stimulates the adrenal cortex to produce and release cortisol and androgens.
Cytochemical identification of human and murine pituitary corticotrophs
and somatotrophs as APUD cells.
It is possible that their hypocortisolic state is related to prolonged compression and irreversible damage to the corticotrophs