Then came the diagnosis of corticobasal
degeneration (CBD) - a rare brain condition that currently affects only 100 people in the UK.
Autophagy maintains neuronal homeostasis, and its role in the turnover of aggregated proteins is important but controversial in neurodegenerative disorders, including AD, Parkinson's disease, amyotrophic lateral sclerosis, and corticobasal
Cognition in corticobasal
syndrome and progressive supranuclear palsy: A review.
Taylor, "Analysis of recurrent corticobasal
ganglia-thalamic loops for working memory," Biological Cybernetics, vol.
The effect of repeated administrations of granulocyte colony stimulating factor for blood stem cells mobilization in patients with progressive supra-nuclear palsy, corticobasal
degeneration and multiple system atrophy.
7% 5,290 CNS-LS: Center for Neurological Study-Liability Scale; PBA: pseudobulbar affect Source: References 1,12 Table 3 Other disease states and injuries that have been associated with PBA Acute demyelinating encephalomyelitis Central pontine myelinolysis Cerebral aneurysms Cerebral arteriovenous malformations Cerebral palsy Cerebral tumors Chemotherapy Corticobasal
degeneration Deep brain stimulation Frontotemporal dementia Herpes encephalitis Huntington's disease Lipid storage diseases Neurosyphilis Normal pressure hydrocephalus Primary lateral sclerosis Progressive supranuclear palsy Wilson's disease PBA: pseudobulbar affect Source: References 12-14
Alzheimer Disease Sourcebook: Basic Consumer Health Information About Alzheimer Disease and Other Forms of Dementia, Including Mild Cognitive Impairment, Corticobasal
Degeneration, Dementia With Lewy Bodies, and Vascular Dementia, Dementia Caused by Infections, and Other Health Conditions That Cause Dementia.
Abnormal accumulation of altered tau protein is a leading indicator in a variety of neurodegenerative conditions including Alzheimer's Disease, Progressive Supranuclear Palsy and Corticobasal
Wenning, Litvan, and Tolosa (2011) clarify that atypical parkinsonian disorders refer to the following neurodegenerative illnesses: multiple system atrophy, dementia with Lewy bodies, PSP, and corticobasal
Parkinson's Disease, Parkinson Plus Syndromes like Progressive Supranuclear Palsy (PSP), Multisystem Atrophy Parkinson's type (MSA-P), Corticobasal
Degeneration (CBD), Huntington's Chorea, Wilson's Disease, Hallervorden-Spatz Disease and Normal Pressure Hydrocephalus (NPH).
He has been diagnosed with a neurodegenerative disease called corticobasal
Besides that, there are studies suggesting that DBS leads to neural plasticity in motor cortex and in modulating corticobasal
circuits [38, 39].