While doing research at the University of Toronto, we hypothesized that cerumen impaction is not a result of overproduction in the ceruminous glands, but a failure of individual corneocytes
in the stratum corneum to separate.
Using modern confocal microscopy and both 2-D and 3-D fluorescence microscopy with corrected values for cellular swelling, it was found that corneocyte
arrangement showed partial column-like alignments, but less than that assumed in earlier structural models.
The SC, with its corneocytes
and lipid matrix and the TJs of the SG constitute the EPB function of the epidermis.
It can be described as a brick wall-like structure where "bricks" represent the terminally differentiated corneocytes
and the "cement" corresponds to the highly specialized intercellular lipids.
Proper exfoliation is essential to inhibit and reduce the cohesion of corneocytes
and the plugging of keratinocytes that occurs in the epidermis and prevents active ingredients from reaching their targeted cell receptors.
But in babies who are predisposed to atopic eczema, this does not work as effectively, allowing loss of water from the corneocytes
(cells in the skin), which shrink and allow cracks to open between them, so irritants and allergens can A[degrees]penetrate, leading to lesions from eczema.
On their way to becoming corneocytes
in the SC, the keratinocytes extrude lipids to form intercellular lamellar lipid layers, and it is this combination of cells and lipids that produces the hydrophobic barrier function of the skin.
It also contains dead cells called corneocytes
, which store large amounts of water and ensure that the fetus does not become dehydrated.
The stratum corneum layer of skin is composed of multi-lamellar lipidic structure punctuated by dead proteinaceous corneocytes
that impose a significant tortuosity on the diffusion path across the membrane .
Her team assessed sebum secretion, took examples of corneocytes
, mapped skin surface contours, evaluated ridges and furrows in the skin, took microscopic pictures and assessed follicular plugs, Dr Kikuchi said.