corneal stroma


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corneal stroma 

The thickest layer of the cornea located behind Bowman's layer and in front of Descemet's membrane. It represents approximately 90% of the total corneal thickness and gives the cornea its strength. The stroma consists of about 300 lamellae of parallel collagen fibrils in the centre of the cornea reaching to nearly 500 lamellae at the limbus. In between the fibrils are proteoglycans whose core proteins bind one with keratan sulfate and the other with dermatan sulfate (chondroitin sulfate B). The orientation of the alternate lamellae differs with each other, but they are all parallel with the corneal surface. In the central part of the cornea the majority of the collagen fibrils are orientated in the inferior-superior and nasal-temporal directions, whereas at the limbus they are orientated circumferentially, providing greater resistance to forces perpendicular to the axes of the fibrils. Between the lamellae are found the elongated flattened keratocytes (corneal corpuscles) from which the collagen fibrils are produced during development. When the cornea becomes oedematous due to trauma, disease or hypoxia, some of the fibrils lose their usual uniform calibre, become displaced and fluid accumulates between the lamellae, the stroma then loses its transparency. Syn. substantia propria.
References in periodicals archive ?
Hence, FED is a disease of Descemet's membrane and endothelial cells, while changes in the corneal stroma and epithelium are secondary to the endothelial dysfunction.
14) After a traumatic incident, the fungal organisms are able to adhere to the exposed corneal stroma and penetrate more deeply, which can lead to corneal perforation.
The new layer is located at the back of the cornea between the corneal stroma and Descemet's membrane.
The study shows that the new layer, is located at the back of the cornea between the corneal stroma and Descemet's membrane, makes an important contribution to the sieve-like trabecular meshwork in the cornea.
Scientists previously believed the cornea to be composed of five layers, from front to back, the corneal epithelium, Bowman's layer, the corneal stroma, Descemet's membrane and the corneal endothelium.
Sclerosing keratitis: This is characterised by peripheral thickening and opacification of the corneal stroma adjacent to the site of scleritis.
It consists of producing a corneal flap, ablating the underlying corneal stroma using laser energy, and repositioning the flap without suturing it to the underlying stroma.
Stromal puncturing -- a procedure involving the physician puncturing the anterior corneal stroma, can also be used but can fail or result in permanent visual loss.
Chief among these approaches is the Presbia Flexivue Microlens[TM], a 3mm-diameter lens that is implanted in the corneal stroma of the patient's non-dominant eye using femtosecond laser technology.
This article concentrates on when to refer patients with keratoconus and outlines the relevance of the Athens protocol, a treatment modality that reshapes the corneal surface and strengthens the corneal stroma.
Dua's layer adds to the five previously known layers of the cornea: the corneal epithelium at the very front, followed by Bowman's layer, the corneal stroma, Descemet's membrane and the corneal endothelium at the very back.
Chief among these approaches is the Presbia Flexivue Microlens, a 3mm-diameter lens that is implanted in the corneal stroma of the patient's non-dominant eye using femtosecond laser technology.