A reduction in corneal sensitivity
or complete corneal anesthesia is the hallmark of this disease and is responsible for producing corneal ulceration, perforation, pain and impaired vision.
To evaluate corneal sensitivity
(recorded as present, absent, or diminished) before application of topical anesthetic, a wisp of cotton formed from a cotton-tipped applicator was used to gently touch the central cornea.
In these patients, eye dryness is due to decreased corneal sensitivity
and reduced tear secretion after stimulation of the corneal surface .
The results show that corneal lesions healed in three quarters of patients, with an increase in corneal sensitivity
Although the data are still "masked" and, therefore, it is not yet known which patients received rhNGF and which received the placebo, complete resolution of corneal lesions was recorded in the majority of patients, with similar percentages in the two groups treated with rhNGF at different doses, as well as an increase in corneal sensitivity
in approximately one in every three patients.
It has already been established that an alteration in corneal sensitivity
blocks lacrimal gland protein, electrolyte, and water secretion (Dartt 2009).
Diabetic neuropathy was associated with progressive, significant reductions in corneal sensitivity
(as measured by non-contact corneal aesthesiometry), nerve fiber density, nerve branch density, and nerve fiber length.
Neurotrophic keratopathy is a degenerative eye disease characterized by decreased corneal sensitivity
and poor corneal healing.
It causes a reduction in corneal sensitivity
and photophobia, with recurrent corneal erosions.
Greater return of corneal sensitivity
with Epi-LASIK procedure than with LASIK
In addition, MIM-D3 may have additional benefits than currently available dry eye therapies including the potential to improve neural function, which may improve corneal sensitivity
Furthermore, there is a reduction in reflex tearing, which may be due to a decrease in corneal sensitivity