corneal dystrophy


Also found in: Dictionary, Wikipedia.
Related to corneal dystrophy: granular corneal dystrophy, corneal degeneration

cor·ne·al dys·tro·phy

[MIM*217600]
central corneal opacification, usually bilateral, symmetric, involving predominantly epithelial, stromal, or endothelial layers, often in a typical pattern; autosomal recessive inheritance.

corneal dystrophy

One of a range of conditions in which any of the three main layers of the cornea may be affected by a disorder of growth or development. Dystrophies usually interfere with the transparency or optical efficiency of the cornea and commonly damage vision. A few are very painful but most are painless. Some dystrophies can be readily treated by CORNEAL GRAFT.

corneal

pertaining to the cornea. See also keratitis, keratopathy.

corneal anomaly
includes microcornea, coloboma, megalocornea, dermoid, congenital opacity.
corneal black body
see corneal sequestrum (below).
corneal coloboma
an uncommon congenital defect in the continuity of the cornea; may have concurrent herniation of the uveal tract. See also coloboma.
corneal dystrophy
a developmental condition, inherited in some breeds of dogs and cats. May cause corneal edema and ulceration. See also keratopathy.
corneal ectasia
corneal edema
occurs when fluid accumulates in the corneal stroma, disrupting the normal lamellar structure and causing a loss of transparency. Commonly called blue eye.
corneal erosion syndrome
see refractory ulcer.
feline focal corneal necrosis
see corneal sequestrum (below).
corneal hyaline membrane
an abnormal, semitransparent membrane on the posterior surface of the cornea, attached to the endothelium. Can be associated with persistent pupillary membrane. Caused by inflammation or a developmental defect.
corneal inflammation
inherited corneal opacity
congenital opacity of the cornea occurs in cattle. The animals are not completely blind and the rest of the eye is normal. Both eyes are affected. The lesion is an edema of the corneal lamellae.
corneal laminae
the limiting membranes that separate the bulk of the cornea from the covering epithelia; the anterior is Bowman's, the posterior is descemet's membrane.
corneal lipidosis
cholesterol crystals and lipid vacuoles may be found in the corneal stroma as a result of persistent hypercholesterolemia or chronic stromal inflammation.
melting corneal
see collagenase ulcer.
corneal mummification
see corneal sequestrum (below).
corneal opacity
corneal pigmentation
results from chronic irritation. The melanin is in the superficial stroma and the basal layer of the corneal epithelium. See also superficial pigmentary keratitis.
corneal reflex
a reflex action of the eye resulting in automatic closing of the eyelids when the cornea is stimulated. The corneal reflex can be elicited in a normal animal by gently touching the cornea with a wisp of cotton. Absence of the corneal reflex indicates deep coma or injury of one of the nerves carrying the reflex arc.
corneal ring abscess
an infected corneal ulcer in which there is a surrounding zone of liquefaction encircled by a zone of neutrophils.
corneal scar
corneal opacity.
corneal sequestrum
a central, focal, dark necrotic plaque on the cornea of cats, especially Persians, associated with chronic ulcerative or inflammatory disease of the cornea. Called also focal superficial necrosis, corneal mummification, keratitis nigrum.
corneal shield
protection used in the treatment of corneal ulcers or wounds; commercial products consisting of collagen which is dissolved in the tear film are claimed to enhance healing.
corneal stromal depositions
minerals, lipids or pigment deposited in the stroma following injury.
superficial corneal erosion
see refractory ulcer.
corneal tattooing
done mainly in horses to obscure unsightly scarring of the cornea.
corneal transparency
the quality of being able to see objects through the cornea; partly the result of the strict horizontal lamellal distribution of its collagen fibers, parallel to the corneal surface.
corneal transplantation
corneal ulcer
a defect in the corneal epithelium and some amount of stroma; may be caused by trauma, chronic irritation as from distichiasis, entropion or keratitis sicca, or infectious agents. Deep ulcers can lead to rupture of the cornea, the escape of aqueous humor and often prolapse of the iris with a secondary uveitis and endophthalmitis. See also ulcer.
Enlarge picture
Corneal ulcer in a horse. By permission from Knottenbelt DC, Pascoe RR, Diseases and Disorders of the Horse, Saunders, 2003
corneal vascularization
results from inflammation of the cornea, the vessels growing in from the limbus. It is a necessary repair process but it reduces visual acuity.
References in periodicals archive ?
Currently focused on commercialization, the company has tested more than 500,000 patients for inherited corneal dystrophy with its DNA safety test to date and protected over 500 positive patients from complications and loss of vision.
I expected all of the groups to limit their activities due to a fear of falling but I was a bit surprised that the group with Fuchs corneal dystrophy was the most likely to limit their activities," said Ellen E.
We are looking forward to working with Dundee University in hopefully developing new treatments and therapies for corneal dystrophy.
INHERITED CONDITION THAT AFFECTS INNER LAYER OF THE CORNEA FUCHS' corneal dystrophy is an inherited condition which affects the delicate inner layer of the cornea.
By means of eye examinations and tissue samples, they have discovered that genetic mutations in either of two genes are responsible for the disease, which has come to be known as Meesmann's corneal dystrophy.
Quite an improvement from the old way, when treating corneal dystrophy meant keeping a donated eye on ice and performing a transplant of the clear disc that allows people to see.
Avellino Labs, as the prime mover in DNA testing for eye care, set the standard for the industry with its test for Granular Corneal Dystrophy and is raising the bar by adding the ability to test for Lattice and two other rare corneal dystrophy variants with the Universal Test," commented Gene Lee, Chairman and Founder of Avellino Labs.
London, August 29 (ANI): A new study has found the gene likely responsible for Fuchs corneal dystrophy, an inheritable genetic disorder and leading cause of corneal transplant operations.
Corneal dystrophy is where the corneal membrane thickens, and again no treatment is necessary.
About Avellino Labs Avellino Labs has developed the first and only commercially available testing system, the DNA Test for LASIK and Refractive Surgery Safety, for Granular Corneal Dystrophy type 1 (GCD1) and Granular Corneal Dystrophy type 2 (GCD2), also known as Avellino Corneal Dystrophy (ACD).
After lunch, we moved on to meet a furry array of smaller patients, including a Cavalier King Charles Spaniel with corneal dystrophy, a yellow Labrador with the canine equivalent of retinitis pigmentosa and a cat called Frodo with a mysterious unilateral anisocoria who gave us an opportunity to practise our diagnostic skills.
Genetic Test for Refractive Surgery Safety has Screened Nearly a half-million Patients for Granular Corneal Dystrophy with 450 Positive Results

Full browser ?