Other studies designed to identify potential SS18-SSX binding partners revealed that SS18-SSX acts as a bridge between the transcription corepressors
ATF2 and TLE1, thereby down-regulating ATF3, EGR1, and CDKN2A.
Hir1p and Hir2p function as transcriptional corepressors
to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle.
In the absence of any ligand, nuclear corepressors
bind PPAR/RXR heterodimers and recruit histone deactylases to down regulate gene transcription (Yu et al.
It is thought to play a vital role in key cellular functions, including growth, antiapoptosis, and inflammation through mediating the exchange of corepressors
To suppress AhR transcription pharmacologically several approaches have been proposed, including the modulation of protein-protein interaction between transcription factor, coactivators, and corepressors
[160, 167, 181].
These co-regulatory proteins consist of corepressors
and coactivators which either repress or activate the transcription respectively.
BPA can disturb thyroid hormone function by reducing T3 binding to the nuclear thyroid receptors (TRs) and recruited nuclear corepressors
(N-CoRs) to the IRs, resulting in transcriptional inhibition.
CtBP family proteins: More than transcriptional corepressors
Unliganded hPXR was able to interact with the corepressors
nuclear receptor corepressor
(NCoR) and silencing mediator of retinoid and thyroid hormone (SMRT; Figure IF).
1997) Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors
, nuclear receptor-corepressor
(NCoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT).
REST and its corepressors
mediate plasticity of neuronal gene chromatin throughout neurogenesis.
The researchers say their results are a milestone in our understanding of certain fundamental mechanisms of living organisms, in particular the little-studied role of corepressors