corepressor


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Related to corepressor: inducer, coactivator

corepressor

 [ko″re-pres´ser]
a small molecule that combines with a protein aporepressor molecule to form an active substance, which then binds to an operator gene and inhibits the synthesis of an enzyme.

co·re·pres·sor

(kō'rē-pres'ŏr),
A molecule, usually a product of a specific metabolic pathway (for example, nuclear protein), which combines with and activates a repressor produced by a regulator gene. The activated repressor then attaches to an operator gene site and inhibits activity of the structural genes. This homeostatic mechanism negatively regulates enzyme production in repressible enzyme systems.

corepressor

/co·re·pres·sor/ (ko″re-pres´er) in genetic theory, a small molecule that combines with an aporepressor to form the complete repressor.

corepressor

(kō′rĭ-prĕs′ər)
n.
A substance that combines with and activates a genetic repressor, thus preventing gene transcription and inhibiting protein synthesis.

co·re·pres·sor

(kō'rĕ-pres'ŏr)
A molecule, usually a product of a specific metabolic pathway, which combines with and activates a repressor produced by a regulator gene. The repressor then attaches to an operator gene site and inhibits activity of the structural genes. This homeostatic mechanism regulates enzyme production in repressible enzyme systems.

corepressor

a substance of low molecular weight which unites with an APOREPRESSOR and reduces the activity of particular structural genes (see OPERON MODEL).

corepressor

a substance (e.g. the product of a metabolic pathway) that activates a repressor by combining with it.
References in periodicals archive ?
Role of coactivators and corepressors in the mechanism of steroid/thyroid receptor action.
Regulation of corepressor function by nuclear NADH.
These authors found that the AR could regulate gene expression through a 3-step pathway that includes miRNA activation, corepressor suppression, and DNA interaction (72).
People have slightly different proportions of coactivators and corepressors.
The latter group of genes includes those encoding proteins forming so-called transcription corepressor complexes (TCCs), which help suppress transcription by coupling HDAC activity with DNA methylation, thereby establishing a repressive chromatin state (McDonel et al.
Unliganded hPXR was able to interact with the corepressors nuclear receptor corepressor (NCoR) and silencing mediator of retinoid and thyroid hormone (SMRT; Figure IF).
CytRx has exclusive rights to intellectual property covering a drug screening method targeting RIP140, a nuclear hormone corepressor that regulates fat accumulation.
Corepressor requirement and thyroid hormone receptor function during Xenopus development.
Specifically, BPA can inhibit the ability of TH to regulate gene expression by inhibiting the release of the corepressor N-CoR from the TR.
Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor.