coreceptor


Also found in: Wikipedia.

co·re·cep·tor

(kō'rē-sep'tōr),
A cell surface receptor, which, when bound to its respective ligand, modulates antigen receptor binding or affects cellular activation after antigen-receptor interactions.

co·re·cep·tor

(kō'rĕ-sep'tŏr)
A cell surface protein that increases the sensitivity of the antigen receptor to antigen by binding to other ligands.

coreceptor

(ko?re-sep'tor) [ com- + receptor]
A structure on a cell membrane that enhances the action of the cell receptor.

CCR5 coreceptor

A cell surface receptor found on macrophages that facilitates entry of HIV-1 into these cells. Chemokines released by T cells attempt to compete with HIV by blocking the receptor to prevent infection.

CXCR4 coreceptor

A cell surface receptor found on T cells that facilitates entry of HIV-1into these cells.
Synonym: fusin
References in periodicals archive ?
Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1.
A) We hypothesize that high levels of immune activation predispose for a coreceptor switch.
Antiretroviral-free remission had previously been achieved in a patient who received an HSCT from a donor with a homozygous 32-base pair deletion in the gene encoding CCR5, a coreceptor for HIV-1.
The protein fibroblast growth factor-23 (FGF-23) (5) and its coreceptor Klotho have attracted great attention in recent years and are currently recognized as playing a key role in the regulation of phosphatemia.
Summary of Study Results In the study, T-cells from HIV subjects were isolated and edited with ZFNs to make them resistant to the virus by knocking out the CCR5 gene which encodes a coreceptor required for HIV infection.
Neuropilin-1 (NRP-1) was found to be a receptor or coreceptor for the specific isoform VEGF165 and expressed on endothelial cells (ECs) and several types of tumor cells.
The earliest studies exploring heritability of response to ART examined variation in HIV coreceptor alleles CCR5 and CXCR4.
Normally, this gene encodes the lymphocyte transmembrane coreceptor to which HIV can bind (Dean et al.
The first link between Wnt signaling and human bone disease came from the observations that inactivating mutations in the Wnt coreceptor, LRP5, cause the osteoporosis-pseudoglioma syndrome (51).
Alcohol exposure increases the number of cells with the CXCR4 coreceptor, resulting in enhanced early replication of viral subtypes that use CXCR4 as a coreceptor (Liu et al.
Activation and coreceptor expression of T lymphocytes induced by highly active antiretroviral therapy in Chinese HIV/AIDS patients.