core promoter

core promoter

A discrete sequence of DNA nucleotides which controls RNA polymerase’s ability to initiate transcription in all eukaryotes—from yeast and Saccharomyces cerevisiae, to complex multi-celled organisms—acting as the site where RNA polymerase begins its activity, serving as an “ignition switch”.
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Other core promoter elements such as potential transcriptional start site for the HSPA6 gene were found including the canonical TATA-box, DPE, MTE, BRE, CpG island, palindromic and repeated sequences.
Mutations in certain regions of the HBV genome, such as in the pre-core and in the basal core promoter (BCP), may disrupt the expression of viral proteins.
precore stop codon mutations, basal core promoter mutations, deletions in the pre-S gene region) gradually increases with the progression of disease through the different clinical stages (1,2).
Mutations in the core promoter region of hepatitis B virus in patients with chronic hepatitis B.
We and others have reported that HBV mutations C1653T, T1753V, A1762T/G1764A, T1674C/G, and C1766T/T1768A in the enhancer II/basal core promoter (EnhII/BCP) region; G1899A, C2002T, A2159G, A2189C, and G2203A/T in the precore/core region; as well as T53C, preS2 start codon mutation, preS1 deletion, C2964A, A2962G, C3116T, and C7A in the preS region of HBV genome are significantly associated with an increased risk of HCC.
We have recently analyzed the expression patterns and the core promoter region of MMP9 gene in chicken ovary (Zhu et al.
A study showed that double mutations of HBV at nucleotide 1762 and 1764 in the Basal Core Promoter (BCP) region were the most common mutation types in HCC patients (7).
Clinical significance of hepatitis B virus (HBV) genotypes and precore and core promoter mutations affecting HBV e antigen expression in Taiwan.
Kadonaga has made many fundamental contributions to the areas of transcriptional regulation and chromatin structure, including the development of sequence-specific DNA affinity chromatography, cloning of transcription factor Sp1, discovery of the downstream core promoter element (DPE), the use of chromatin templates to recreate ligand-regulated transcription by nuclear factors in vitro, and the cloning of factors that mediate chromatin assembly.
8-10) Moreover, several studies have shown a strong relationship between HBV genotypes and mutations in the pre-core and core promoter regions that abolish or diminish the production of hepatitis B e antigen (HBeAg).
All viruses had precore stop codon or basal core promoter mutations.
Associate membership is limited to 50 companies, and is obtained by invitation from one of the SIG's core promoter groups.