copy number

copy number

  1. the number of copies of a particular PLASMID per CHROMOSOME present in a CELL.
  2. the number of copies of a GENE in the GENOME of an ORGANISM.

copy number

the number of plasmid or other DNA molecules in a cell.
References in periodicals archive ?
Milford, Massachusetts-based life sciences company SeraCare Life Sciences has expanded its suite of clinical genomics development, validation, and QC tools with the launch of dedicated copy number variations (CNV) reference materials for NGS assays - Seraseq Breast CNV Mix, and Seraseq Lung and Brain CNV Mix, the company said.
In the present study, we aimed to establish the normal reference range of mtDNA copy number in the Chinese population.
The mtDNA copy number has a link with oocyte quality and plays vital role in production of ATP within the oocyte (20, 21).
The findings, published June 22, 2017, in PLoS Genetics, suggest that ribosomal DNA copy number could be used to predict which cancers will be sensitive to DNA-damaging chemotherapeutics.
Each of 158 cases and 147 controls were genetically scored for genetic deletions, duplications, and total changes in copy number.
The scientific team conducted genetic analyses on 2,434 individuals with Tourette syndrome and compared them to 4,093 controls, focusing on copy number variants, changes in the genetic code resulting in deletions or duplications in sections of genes.
Targeted genes are enriched by hybrid capture for sequencing and are designed to detect single-nucleotide variants, insertions and deletions, copy number variations, and a limited number of structural variants.
Hence, an abnormal result from the count-based approach could result from more than one clinical scenario, namely the presence of a copy number aberration (CNA) in (a) the fetus, (b) the mother, or (c) both (8, 10).
Furthermore, using DNA copy number and expression data obtained from The Cancer Genome Atlas project, Snijders and Mao observed that a genetic process called amplification is a major mechanism driving overexpression of these 18 genes in majority of cancers.
In a variety of tumors, increasing the copy number of the TERT has clinical relevance and prognosis For example, Zhu and his colleagues have shown that Lung Cancer Patients with increased amplification of hTERT with reoccurs will not last long.
Seemingly similar cells, especially cancer cells, often have significantly different genetic mutations and therefore detailed knowledge of these mutations, called copy number variations (CNVs), in individual cells can point to specific treatment regimens, said the study published in the journal Nature Methods.
Copy number variations, changes in the frequency of particular genetic sequences, are a critical element for pharmacogenomics, as they can have a significant impact on human phenotypes, including links to a variety of diseases such as cancer, (1) schizophrenia, (2) and autism.