coproporphyrin

coproporphyrin

 [kop″ro-por´fĭ-rin]
a porphyrin occurring as several isomers; the III isomer, an intermediate in heme biosynthesis, is excreted in the feces and urine in hereditary coproporphyria and variegate porphyria; the I isomer, a side product, is excreted in the feces and urine in congenital erythropoietic porphyria.

cop·ro·por·phy·rin

(kop'rō-pōr'fi-rin),
One of two porphyrin compounds found normally in feces as a decomposition product of bilirubin (hence, from hemoglobin); certain corproporphyrins are elevated in certain porphyrias.
See also: porphyrinogens.

coproporphyrin

/cop·ro·por·phy·rin/ (-por´fĭ-rin) a porphyrin occurring as several isomers; the III isomer, an intermediate in heme biosynthesis, is excreted in the feces and urine in hereditary coproporphyria and variegate porphyria; the I isomer, a side product, is excreted in the feces and urine in congenital erythropoietic porphyria.

coproporphyrin

[kop′rōpôr′firin]
Etymology: Gk, kopros + porphyros, purple
1 any of the nitrogenous organic substances normally excreted in the feces that are products of the breakdown of bilirubin from hemoglobin decomposition.
2 a test used to measure red blood cell porphyrin levels.

cop·ro·por·phy·rin

(kop'rō-pōr'fĭr-in)
One of two porphyrin compounds found normally in feces as a decomposition product of bilirubin (hence, from hemoglobin); certain coproporphyrins are elevated in certain porphyrias.
See also: porphyrinogens

cop·ro·por·phy·rin

(kop'rō-pōr'fĭr-in)
One of two porphyrin compounds found normally in feces as a decomposition product of bilirubin.

coproporphyrin (kop´rəpor´firin),

n a nitrogenous organic substance normally excreted in the feces as a breakdown of bilirubin.

coproporphyrin

a porphyrin formed in the blood-forming organs and intestine and found in the urine and feces. There are two chemically distinct substances, coproporphyrins I and III.
References in periodicals archive ?
Identification of zinc coproporphyrin as a marker for meconium.
An unexpected new property of tetrapyrroles, including tetramethyl coproporphyrin III, tetrabenzoporphine, copper chlorin e4 ethyl ester, and of carotenoids including zeaxanthin and alpha-cryptoxanthin is their ability to induce mammalian phase 2 proteins that protect cells against oxidants and electrophiles.
6) Abnormal porphyrin metabolism, a characteristic of diseases usually inherited as an enzyme deficiency and resulting in abnormal synthesis of photodynamic agents, including uroporphyrin and coproporphyrin, can result in photosensitization.
Elevated urinary concentrations of coproporphyrin, hexacarboxylporphyrin, and pentacarboxylporphyrin were significantly associated with autism but not with PDD-NOS.
acnes naturally produces high amounts of intracellular porphyrins, mostly coproporphyrin (Ashkenazi et al.
Inhibition of these enzymes by Hg poisoning results in specific elevations of coproporphyrin and pentacarboxyporphyrin in the urine.
Urinary excretion of 5-hydroxyindoleacetic acid, delta-aminolevunilic acid and coproporphyrin isomers in rats and men exposed to lead.
MacDonald was gleeful when he degraded $106 worth of uro III in a single 250 ml flask to coproporphyrin III, a reference compound used worldwide in biochemical studies.
An EPNET specialist porphyria laboratory/center must be able to distinguish between all types of porphyria, requiring performance of the following analyses: urinary [delta]-aminolevulinic acid (ALA), porphobilinogen (PBG) and porphyrins (total/fractionation), fecal porphyrins (total/fractionation including coproporphyrin isomer differentiation), erythrocyte protoporphyrin (total/fractionation), and plasma fluorescence scanning.
These changes are characterized by dose- and time-related increases in urinary concentrations of pentacarboxyl (5-carboxyl) and copro- (4-carboxyl) porphyrins and also by the appearance of precoproporphyrin, an atypical porphyrin [molecular weight (mw) = 668] that elutes on high-performance liquid chromatography (HPLC) prior to coproporphyrin (mw = 655) (Woods et al.
PbAs had additive effects on urinary excretion of coproporphyrin, but less than additive for uroporphyrin.