The PCSK9 gene was first identified by virtue of its homology to other genes of the protein convertase
Furin is a ubiquitous proprotein convertase
enriched in the trans-Golgi network and is well-conserved among mammals (20).
Subtilisin-like Proprotein Convertases
(SPCs) are a family of eukaryotic endoproteases that function in the secretory pathway.
She has a mutant gene for prohormone convertase
1, an enzyme that activates certain proteins, including insulin, as the final step in their production.
PCSK9 (proprotein convertase
subtilisin/kexin type 9) is a protein that regulates low-density lipoprotein (LDL) receptor levels on hepatocytes; gain-of-function human mutations in PCSK9 are associated with hypercholesterolemia while loss-of-function mutations are associated with lower levels of LDL cholesterol and a reduced risk of cardiovascular disease.
evolocumab) is a human monoclonal antibody that inhibits proprotein convertase
subtilisin/kexin type 9 (PCSK9).
TM) ](evolocumab), the first proprotein convertase
subtilisin/kexin type 9 (PCSK9) inhibitor to be approved in the world, for the treatment of patients with uncontrolled cholesterol who require additional intensive low-density lipoprotein cholesterol (LDL-C) reduction.
It is clear that these proprotein convertase
subtilisin/kexin type 9 (PCSK9) inhibitors provide a powerful therapy for reducing LDL cholesterol, with a reported decrease of about 60% after only 12 or 52 weeks of treatment.
This lack of consensus is further complicated by growing evidence that the current NT-proBNP immunoassays may detect blood proBNP in HF patients, which is caused by the lack of processing of the precursor proBNP by furin and corin protease convertase
present in the circulation (6-8).
GP-C was posttranscriptionally processed by S1P (the cellular proprotein convertase
site 1 protease) to yield the glycoproteins, and the consensus motif R-(R/K/ H)-L-(A/L/S/T/F) was identified as the S1P recognition site of Luna virus glycoprotein (11,12).
Partial Purification and Characterization of Secreted Proprotein Convertase
Furin and PACE4.
When complement proteins are triggered into action by a microbe, the proteins ultimately form a complex enzyme called C3 convertase
, which triggers a cascade of immune and inflammatory reactions.