DPX-120 was a single-center, double-blind study in healthy adult subjects with the primary objective of evaluating the potential of Locilex and its vehicle cream to induce contact sensitization
by repetitive application to human skin.
In 2005 IFRA introduced a new Quantitative Risk Assessment or QRA approach to restrict fragrance materials that have a potential to induce contact sensitization
Prevalance and source of occupational contact sensitization
to acrylates in Italy.
Mantovani L: Contact sensitization
in 1094 children undergoing patch testing over a 7-year period.
In trials, there was one report of an allergic reaction in a patient who stopped using the patch because of irritation at the site of the patch that reappeared at the same site after starting on oral methylphenidate, a sign of contact sensitization
, said Dr.
Results from this trial indicated that Vibrilase produced no evidence of contact sensitization
or irritation for up to eight days, well beyond the expected one to three day treatment period in which Vibrilase would be applied.
These studies suggest the potential for methyl red to induce contact sensitization
Is there an increased skin irritation and contact sensitization
in atopic dermatitis?
Suppression of contact sensitization
in man by prior feeding of antigen.
In clinical trials, the most commonly reported adverse events associated with use of Metvixia PDT were contact sensitization
, erythema, pain, burning, and skin discomfort/irritation.
The QRA is a vast improvement over the former approach because it is quantitative, exposure based, consistent with modern principles of toxicologic risk assessment, suitable for assessing contact sensitization
and applicable to various factors such as different product types and use patterns.
I think the reason why many people think that the risk of contact sensitization
in children is lower than in adults has to do with the fact that people have always thought that the immune system of younger children wasn't capable of reacting to these agents," says Bernard A.