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contact inhibition

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inhibition /in·hi·bi·tion/ (in″hĭ-bish´un)
1. arrest or restraint of a process.
2. in psychoanalytic theory, the conscious or unconscious restraining of an impulse or desire.

competitive inhibition  inhibition of enzyme activity in which the inhibitor (a substrate analogue) competes with the substrate for binding sites on the enzymes.
contact inhibition  inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
endproduct inhibition , feedback inhibition inhibition of the initial steps of a process by an endproduct of the reaction.
noncompetitive inhibition  inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.

contact inhibition
n.
Cessation of replication of dividing cells that come into contact.

inhibition [in″hĭ-bish´un]
1. arrest or restraint of a process.
2. in psychoanalysis, the conscious or unconscious restraining of an impulse or desire. adj., adj inhib´itory.
competitive inhibition inhibition of enzyme activity by an inhibitor (a substrate analogue) that competes with the substrate for binding sites on the enzymes.
contact inhibition inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
noncompetitive inhibition inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.

inhibition
arrest or restraint of a process.

competitive inhibition
inhibition of enzyme activity by an inhibitor (a substrate analog) that competes with the substrate for binding sites on the enzymes.
contact inhibition
inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
end-product inhibition
see feedback inhibition (below).
feedback inhibition
a common way of regulating enzyme activity in which the reaction product (or in the case of a biosynthetic pathway, the product of the reaction sequence) inhibits the enzyme activity. Called also end-product inhibition.
neurological inhibition
the intermittency of transmission of nervous impulses depends on variations in the balance between excitation and inhibition, the latter being either pre- or postsynaptic.
noncompetitive inhibition
inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.


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The researchers also found that contact inhibition in naked mole rats is controlled by two genes, p16 and p27, while in humans it is primarily controlled by p27.
The cells normally grew in the medium containing 10% FCS until reaching contact inhibition and ceased proliferation, then committed to differentiation in 10% HS after 4 days (Fig.
 
 
 
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