These data continue to demonstrate that treatment with CYT387 results in significant, durable responses in transfusion dependency, splenomegaly and constitutional symptoms
," said Dr.
5) However, they did not exclude patients with cervical lymphadenopathy, dysphagia, constitutional symptoms
, unexplained weight loss, or unilateral signs and symptoms.
In addition, many patients experience rapid, meaningful and durable reductions of splenomegaly and improvements of constitutional symptoms
Systemic infection may be accompanied by constitutional symptoms
of fever, sweats, chills, poor appetite, vomiting, diarrhoea, abdominal pain and weight loss.
The patient denied any constitutional symptoms
, and he had no history of scalp or oral lesions, dysphagia, breathing difficulties, or otalgia.
Because renal failure is a common entity, this potential differential diagnostic consideration in patients in endemic areas presenting with diarrhea and constitutional symptoms
warrants a note.
He has no constitutional symptoms
or neurologic complaints.
HGE may cause a postinfectious syndrome characterized by constitutional symptoms
without functional disability or serologic evidence of persistent infection.
Phase I/II data show Incyte's JAK1 and JAK2 inhibitor INCB18424 demonstrates durable clinical benefits including reduction of spleen size and alleviation of debilitating constitutional symptoms
in myelofibrosis patients
He had no constitutional symptoms
, no gross hematuria, weight loss, flank pain or fever.
Pacritinib Shows Activity in Alleviating MF-associated Splenomegaly and Constitutional Symptoms
with Lack of Myelosuppression
Diagnostic tonsillectomy is indicated in children with asymmetrically enlarged tonsils associated with constitutional symptoms
, cervical lymphadenopathy rapid tonsil enlargement or significant tonsillar asymmetry.