Gilbert syndrome

(redirected from constitutional liver dysfunction)

fa·mil·i·al non·he·mo·lyt·ic jaun·dice

[MIM*143500]
mild jaundice due to increased amounts of unconjugated bilirubin in the plasma without evidence of liver damage, biliary obstruction, or hemolysis; thought to be due to an inborn error of metabolism in which the excretion of bilirubin by the liver is defective, ascribed to decreased conjugation of bilirubin as a glucuronide or impaired uptake of hepatic bilirubin; autosomal dominant inheritance.

Gilbert syndrome

A benign hereditary condition (OMIM:143500) in which reduced bilirubin transferase activity results in intermittent hyperbilirubinaemia.

Gilbert syndrome

Constitutional liver dysfunction, low-grade chronic hyperbilirubinemia An inherited defect in bilirubin metabolism Clinical Jaundice, weakness, fatigue, nausea, abdominal pain. Cf Criggler-Najjar disease.

Gilbert,

Nicholas A., French physician, 1858-1927.
Gilbert disease - Synonym(s): familial nonhemolytic jaundice
Gilbert syndrome - Synonym(s): familial nonhemolytic jaundice
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