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constant region

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constant region
n.
The portion of the carboxyl terminal of an immunoglobulin's heavy and light chains having an amino acid sequence that does not vary within a given class or subclass of immunoglobulin.

constant region,
the part of an immunoglobulin in which the amino acid sequence is relatively constant in all molecules of that class of immunoglobulin. Compare variable region.


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L chains of a single chain monoclonal antibody to CD19, Fc represents at least part of a constant region of an IgG.
Each heavy chain has four constant region domains (C[euro]1-C[euro]4).
Using Xencor's PDA[R] technology, researchers engineered the constant region (Fc) of the antibody to increase its affinity for binding FcgRIIb by about 200-fold.
 
 
 
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