constant region

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constant region

The portion of the carboxyl terminal of an immunoglobulin's heavy and light chains having an amino acid sequence that does not vary within a given class or subclass of immunoglobulin.

constant region,

the part of an immunoglobulin in which the amino acid sequence is relatively constant in all molecules of that class of immunoglobulin. Compare variable region.

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The Fc portion of the constant region of the antibody has been shown in previous studies to be responsible for mediating antibody-dependent cell-mediated cytotoxicity and has been the target of Xencor's XmAb technology.

Xencor Data Published in PNAS Show Engineering the ''Fc'' Region of ... by Business Wire

Research has shown that this process, known as antibody dependent cell cytotoxicity (ADCC), is sensitive to the composition of sugars (or "glycans") in the antibody's constant region.

GlycoFi Announces the First Production of Antibodies with Human ... by Business Wire

Anne Dobree, Interim Director of Cambridge Enterprise, said, "We are pleased to have negotiated this license with Xencor, the most innovative company in the rapidly developing field of the engineering of antibody constant regions.

Xencor Strengthens Antibody Therapeutics Patent Portfolio with ... by Business Wire

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