constant domains

constant domains

the C-terminal regions of heavy and light chains of immunoglobulins; they contain the amino acid sequences that are similar in different antibodies of the same class. See also cH domains; cL domain.
References in periodicals archive ?
These heavy-chain antibodies contain a single variable domain (VHH) and two constant domains (CH2 and CH3).
The combination of those variable domains with human constant domains generates full size, human therapeutic antibodies.
Peptibodies are engineered therapeutic molecules that can bind to human drug targets and contain peptides linked to the constant domains of antibodies.
These variable domains are then combined with human constant domains to generate full size, fully human therapeutic antibodies.
These variable domains are combined with human constant domains to generate full size, fully human therapeutic antibodies.

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