Recent studies of RNA molecules that don't code for proteins show that those molecules have definite functions, even though they aren't conserved in the DNA codes of other mammals, said Job Dekker of the University of Massachusetts Medical School in Worcester.
The PathBLAST development group published a paper in the 30 September 2003 issue of Proceedings of the National Academy of Sciences in which they identified the conserved pathways within the yeast Saccharomyces cerevisiae and the bacterium Helicobacter pylori.
Comparison of flavivirus universal primer pairs and development of a rapid, highly sensitive heminested reverse transcription-PCR assay for detection of flavivirus targeted to a conserved region of the NS5 gene sequences.
A protein database search had shown that both tryptophans were not absolutely conserved in all identified viral p19 sequences, although all sequences conserved at least one of the tryptophans, with the other residue usually capable of forming a stacking interaction.
A recent report claims that these sequences have been conserved through hundreds of millions of years of evolution, a fact that suggests they may perform important roles and are worthy of future study.
The first 8 to 13 nucleotide bases at the 3' ends of all three RNA segments have a sequence that is conserved in the viruses of this genus, with a complementary consensus sequence occurring at the 5' end; the ends of the segments are noncovalently linked so that the RNA occurs in a loosely bound circular configuration within the nucleocapsids (11).
These comparisons will promote understanding of molecular evolution, the significance of conserved sequences, the genetic basis of variable sensitivity to environmental agents, and the complex interactions between the environment and human health.