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TEHRAN (FNA)- How does a protein called connexin put the clamps on cancer?
No mutations in connexin genes GJB2, GJB6 or GJA1 among Cameroonians and Xhosa South Africans
In ovaries, connexin 43 (Cx43), encoded by Gja1, has been found to be the main connexin expressed in developing follicles forming the gap junctions coupling granulosa cells (20-23).
Connexins are a family of transmembrane proteins that form intercellular gap junction channels to allow ions and small molecules between adjacent cells.
Our hypothesis is that lycopene's anticarcinogenic properties are due to its ability to enhance Gap Junctional Communication (GJC) between adjacent cells by increasing the available connexin proteins.
The scientists also found that the implanted cells made proteins called connexins, which physically and electrically connect heart cells and aren't found in mature skeletal muscle.
The pores of the gap junction channels, which connect the interiors of 2 cells, are composed of proteins, termed connexins.
Gap junctions are made of connexins (a specialized group of proteins) that align to form a channel from one cell to the next.
The etiology of postoperative AF is not well defined, although recent studies suggest a multi-factorial mechanism, which includes oxidative stress, inflammation, atrial fibrosis, and excessive production of catecholamines, changes in autonomic tone and in the expression of connexins (3, 4).
The length of the volume prevented more than passing reference to the role of connexins in the immune system and in hematopoiesis, and the possible non-channel functions of the protein.
3:00 Ewa Borowczyk (NDSU): GAP JUNCTIONAL PROTEINS CONNEXINS (Cx) 26, 32, 37 AND 43 mRNA EXPRESSION IN THE OVINE OVARIAN FOLLICLES DURING THE PERIOVULATORY PERIOD
New directions in antiarrhythmic therapy being explored for AF include novel formulations of class I antiarrhythmic agents, coupling agents that act upon connexins, specific bradycardic agents, and serotonin receptor antagonists.
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