GJA1

(redirected from connexin-43)

GJA1

A gene on chromosome 6q21-q23.2 that encodes an alpha chain of the gap junction protein family, or connexins.

Molecular pathology
GJA1 mutations are associated with oculodentodigital dysplasia and cardiac malformations.
References in periodicals archive ?
Our recent studies revealed that DEHP adversely affects the synchronicity of a cardiac cell network by disrupting connexin-43, the main component of cardiac gap junctions (Gillum et al.
slowed conduction velocity, induced asynchronous beating, diminished connexin-43 expression).
Changes in gap junction connexin-43 messenger ribonucleic acid levels associated with rat ovarian follicular development as demonstrated by in situ hybridization.
Casein kinase 1 regulates connexin-43 gap junction assembly.
In addition, the experiments showed enhanced production of troponin I, a protein involved in muscle calcium binding and contraction, and connexin-43, a protein involved in electrical coupling between cells that is believed to play a critical role in the development of the heart's architecture and in the synchronized contraction of the heart.
The increased immunoreactivity for connexin-43 was seen 2 days after mild ischemic injury in the rat hippocampus and striatum (Hossain et al.
Comments: Protection of connexin-43 in the epidermis was confirmed by the following: monoclonal antibody assay on keratinocyte culture; detection of the expression of messenger RNA specific to connexin-43 (RT-PCR) on a keratinocyte culture and immunolocalization on human skin explants.