GJA5

(redirected from connexin 40)

GJA5

A gene on chromosome 1q21.1 that encodes an alpha chain of the gap junction protein family or connexins. 

Molecular pathology
GJA5 mutations have been associated with atrial fibrillation.
References in periodicals archive ?
Colocalization of connexin 43 and connexin 45 but absence of connexin 40 in granulosa cell gap junctions of rat ovary.
They discovered genetic mutations in the Connexin 40 gene in AF patients.
Currently, AF is treated with medications that do not specifically target the Connexin 40 protein.
Incompatibility of connexin 40 and 43 hemichannels in gap junctions between mammalian cells is determined by intracellular domains.