If it arises early in the course of connective-tissue disease
, screening blood serum for it might offer an early warning of such diseases, prompting physicians to monitor such patients closely, Hefeneider suggests.
The central lesson of this study is a confirmation that we can exclude any large risk of connective-tissue disease
following breast implants," said Dr.
Researchers also looked at connective-tissue disease
laboratory tests to see if there were significant differences in the two groups of women and found none.
And even if the risk is real, the authors calculate that it would mean only one extra case of connective-tissue disease
, like arthritis or lupus, a year for every 3,000 women with implants.
One of Mariann Hopkins's treating physicians testified that, although her diagnosis of mixed connective-tissue disease
did not come until after the implants were put in, she had already displayed symptoms of connective-tissue disease
as early as two years before receiving implants.
Citing a string of medical studies showing no link between breast implants and certain connective-tissue diseases
, FDA Commissioner David Kessler recently told a congressional subcommittee that there is "reasonable assurance" that implants do not cause "traditional connective-tissue disease
It found no link between implants and connective-tissue disease
However, 2 years ago the Food and Drug Administration triggered a moratorium on the use of these implants when sporadic reports began linking them to connective-tissue disease
and autoimmune disorders.
They also expect new evidence in the coming weeks that will conclusively link silicone and connective-tissue disease
Physicians have long theorized that Marfan's is a connective-tissue disease
The authors also point out that while the mechanism of causation is not yet clear, the development of connective-tissue disease
after silicone-oil injections has been reported.
The investigators stated: "We found no association between breast implants and the connective-tissue diseases
and other disorders that were studied.