conjugated estrogen


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con·ju·gat·ed es·tro·gen

an amorphous preparation of naturally occurring, water-soluble, conjugated forms of mixed estrogens obtained from the urine of pregnant mares (conjugated equine estrogen); the principal estrogen present is sodium estrone sulfate; suitable for parenteral, oral, and topical administration.

conjugated estrogen

[kon′jəgā′tid]
a mixture of sodium salts of estrogen sulfates, chiefly those of estrone, equilin, and 17-alpha-dihydroequilin. Conjugated estrogens may be prescribed to relieve postmenopausal vasomotor symptoms, such as hot flashes; to treat atrophic vaginitis, female hypogonadism, or primary ovarian failure; and to provide palliation in advanced prostatic carcinoma and metastatic breast cancer in selected patients. The drug is also used to treat and prevent osteoporosis. Continued use of estrogens can increase the risk of endometrial carcinoma, gallbladder disease, and thromboembolic disorders. Because of the danger of damage to the fetus, all female sex hormones are contraindicated during pregnancy. Among the adverse effects of conjugated estrogens are breakthrough bleeding, breast tenderness, nausea, headache, water retention, and skin eruptions. Current preliminary evidence suggests that there are no cardiovascular benefits to estrogen use during menopause, evidence that led to early discontinuation of the clinical study and changes in the product labeling. Coronary heart disease, the focus of the study, was actually increased in the treatment group, along with breast cancer, stroke, and thromboembolism. Topical agents rather than systemic estrogen should be used for treating vulvar or vaginal atrophy. Nonestrogen agents are recommended for the treatment and prevention of osteoporosis.

conjugated estrogen

An estrogenic drug, principally estrone and equilin, used to treat menopausal symptoms and to prevent osteoporosis.
See also: estrogen
References in periodicals archive ?
In December 2003, Barr acquired from Endeavor Pharmaceuticals the NDA and intellectual property related to Enjuvia synthetic conjugated estrogens product, and two early stage development female healthcare products.
Three patients on bazedoxifene / conjugated estrogens experienced deep vein thrombosis during 2 years of therapy, as did one on placebo.
1 mg estradiol/g USP, Contract Pharmaceuticals Limited, Buffalo, NY, for Warner Chilcott, LLC); and/or conjugated estrogens vaginal cream (Premarin[sup.
They were randomized to eight arms: bazedoxifene at 10, 20, or 40 mg, each combined with conjugated estrogens at 0.
R]] (synthetic conjugated estrogens, A) Tablets are for use by women after menopause to reduce hot flashes and treat dryness, itching, and burning in and around the vagina.
Data from another Phase 3 study titled "Effects of the TSEC Bazedoxifene and Conjugated Estrogens on Vulvar/Vaginal Atrophy and Sexual Function in Postmenopausal Women," which evaluated 601 postmenopausal women with moderate to severe vulvar and vaginal atrophy, also were presented.
The study found that younger menopausal women (aged 50-59) who received a standard dose of oral conjugated estrogens had significantly less coronary artery calcification at the end of the study period compared with those taking placebo.
As noted in the Drug Update, space limitations prevented separate listings for the oral formulations of conjugated estrogens and estradiol and the transdermal formulation of estradiol.
Results showed that conjugated estrogens alone increased endometrial thickness.
April 11 /PRNewswire-FirstCall/ -- Wyeth Pharmaceuticals, a division of Wyeth , reports that data published today in the Journal of the American Medical Association (JAMA) showed that in the estrogen-alone sub-study of the Women's Health Initiative (WHI), conjugated estrogens 0.
He conducted a study of 60 women aged 45-56 years to determine whether low-dose conjugated estrogens combined with medroxyprogesterone acetate would yield the same bone-protecting benefits in relatively young postmenopausal women as has been observed in older subjects.