Muscle biopsy of the left vastus medialis muscle revealed rimmed vacuoles in muscle fibers with necrosis, regeneration, and congophilic
staining inclusions, consistent with a diagnosis of inclusion body myositis (IBM) (Figures 1 and 2).
Morphologic PrP aggregates, congophilic
materials, or thioflavin-positive deposits were not detected in 113LBoPrP-Tg037 mice.
The specimens from the renal pelvis and bladder showed loss of congophilic
staining when treated with potassium permanganate, consistent with AA amyloid.
Amyloid or congophilic
angiopathy is also commonly seen in AD.
Biopsy findings were those of amyloidoma, with amorphous congophilic deposits and apple green birefringence.
Subtotal resection of the right temporal lobe was then performed, and histology showed congophilic vascular mural deposits of amyloid, with diffuse white matter gliosis and edema.
These findings amply support a neuropathologic diagnosis of cerebral congophilic
Hereditary cerebral hemorrhage with amyloidosis--Dutch type: a congophilic
angiopathy: an overview.