congenital toxoplasmosis


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Related to congenital toxoplasmosis: Congenital rubella

con·gen·i·tal tox·o·plas·mo·sis

toxoplasmosis apparently resulting from parasites in an infected mother being transmitted in utero to the fetus, observed as three syndromes: acute: most of the organs contain foci of necrosis in association with fever, jaundice, hydrocephaly, encephalomyelitis, pneumonitis, cutaneous rash, ophthalmic lesions, hepatomegaly, and splenomegaly; subacute: most of the lesions are partly healed or calcified, but those in the brain and eye seem to remain active, inasmuch as chorioretinitis is observed in more than 80% of diseased infants; and chronic: usually not recognized during the newborn period, but chorioretinitis and cerebral lesions may be detected weeks to years later.

congenital toxoplasmosis

A transplacental infection with the protozoan Toxoplasma gondii affecting ±13 of fetuses of ♀ with acute acquired toxoplasmosis, most severe if the infection occurs in 1st trimester; children are often normal at birth, followed by blindness, mental retardation; it may affect the brain, lung, heart, eyes, liver Clinical Hydrocephalus, microcephaly, cerebral calcifications, atrophy, chorioretinitis, uveitis, vitritis, convulsions, hyperbilirubinemia, hepatomegaly Diagnosis PCR of amniotic fluid to detect 35-fold repeat of the B1 gene of T gondii Sensitivity 97%–vs 90% with conventional parasitology Lab IgM immunoassay Management Pyrimethamine, sulfadiazine, leukovorin. See TORCH.

con·gen·i·tal tox·o·plas·mo·sis

(kŏn-jen'i-tăl tok'sō-plaz-mō'sis)
A disease caused by the protozoan parasite Toxoplasma gondii, which is transmitted in utero to the fetus, observed as three syndromes: 1) acute: most of the organs contain foci of necrosis in association with fever, jaundice, hydrocephaly, encephalomyelitis, pneumonitis, rash, ophthalmic lesions, hepatomegaly, and splenomegaly; 2) subacute: most of these lesions are partly healed or calcified, but those in the brain and eye seem to remain active, inasmuch as chorioretinitis is observed in more than 80% of diseased infants; and 3) chronic: usually not recognized during the newborn period, but chorioretinitis and cerebral lesions may be detected weeks to years later.
References in periodicals archive ?
Low risk of congenital toxoplasmosis in children born to women infected with human immunodeficiency virus.
After electronic and paper charts were reviewed, 2 cases of congenital toxoplasmosis were confirmed.
The purpose of this study was to describe the demographic, clinical, and laboratory characteristics of children with congenital toxoplasmosis that received treatment for congenital toxoplasmosis at one medical center in southern Brazil.
Immunological control of congenital toxoplasmosis in the murine model.
Until rates of congenital toxoplasmosis fall, control measures are essential.
gondii IgM and/or toxoplasma IgG titer equal to or higher than the mother's, underwent transfontanellar ultrasound and a fundoscopic examination to confirm the diagnosis of congenital toxoplasmosis.
strains, which may cause life-threatening primary infection (case-patient 1) or severe congenital toxoplasmosis with atypical outcome of acquired toxoplasmosis in the mother (case-patient 3).
We report a case of congenital toxoplasmosis from reactivation of maternal infection due to severe immunodepression related to HIV infection, including the difficulties in management of both diseases in the affected infant.
Gilbert R, Gras L; European Multicentre Study on Congenital Toxoplasmosis.
Congenital toxoplasmosis is rare on average, less than one case per 1,000 pregnancies, since mother-to-child transmission occurs only when infection is acquired for the first time during pregnancy [1].
Although ventriculitis and consecutive obstructive hydrocephalus are characteristic findings in congenital toxoplasmosis [6], they are rarely seen in adult immunocompromised hosts.
Epidemiology of congenital toxoplasmosis identified by population-based newborn screening in Massachusetts.

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