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1. a hollow or depressed area.
2. a lowering or decrease of functional activity.
3. in psychiatry, a mental state of altered mood characterized by feelings of sadness, despair, and discouragement; distinguished from grief, which is realistic and proportionate to a personal loss. Profound depression may be an illness itself, such as major depressive disorder (see also mood disorders), or it may be symptomatic of another psychiatric disorder, such as schizophrenia. adj., adj depres´sive.

Depression is closely associated with a lack of confidence and self-esteem and with an inability to express strong feelings. Repressed anger is thought to be a powerful contributor to depression. The person feels inadequate to cope with the situations that arise in everyday life and so feels insecure.

Treatment of profound and chronic depression is often very difficult, requiring in most cases intensive psychotherapy to help the patient understand the underlying cause of the depression. antidepressant drugs such as imipramine hydrochloride (Tofranil) and amitriptyline (Elavil) are often used in the treatment of profound depression. They are not true stimulants of the central nervous system, but they do block the reuptake of neurotransmitter substances, which may potentiate the action of norepinephrine and serotonin. monoamine oxidase (MAO) inhibitors are also used. When antidepressants fail, a different technique such as electroconvulsive therapy may be used in conjunction with the psychotherapy.
Patient Care. Mild, sporadic depression is a relatively common phenomenon experienced by almost everyone at some time, but hospitalized patients are particularly susceptible to feelings of depression and a sense of loss and despair. Early signs of depression of this kind include pessimistic statements about one's illness and its prognosis, refusal to eat, diminished concern about personal appearance, and reluctance to make decisions. When depression is noted in a patient, it should be listed on the treatment plan along with suggestions for resolving it.

When patients are depressed, they are likely to isolate themselves and avoid social contact even with those who are trying to help them. Since loss of contact with others contributes to depression, members of the health care team should persist in attempts to talk with these patients, by asking them questions, and actively listening when they attempt to express their feelings. One should be especially careful to avoid being judgmental when the patient does express despair, anger, hostility, or some negative feeling. Above all, it is important not to be condescending or to respond to statements with a meaningless cliché such as “Don't worry,” or “I'm sure everything will turn out okay.” These responses convey a lack of empathy with the patient's suffering and are an unrealistic approach to a problem that is very real.

Physical contact and touching may be misunderstood by depressed patients. Sometimes, it is better just to sit with them and calmly observe them without making them feel uncomfortable. Honest dialogue and expressions of support and concern can often improve their mood and sense of self worth.

Severely depressed patients usually express three basic feelings associated with their mental state. These are a lack of desire for socializing or physical activity, feelings of worthlessness and loss of self esteem, and thoughts of self-injury or destruction. In planning the care of the depressed patient, one must always consider these feelings and strive for some understanding of the reasons for the patient's behavior. Only by gradually gaining their attention and pointing out encouraging signs of progress can they be helped in their early attempts to return to reality and socialize with others.

Physical inactivity will require attention to adequate nutrition, a normal balance of fluid intake and output, proper elimination, and good skin care. Patients will need help in maintaining good personal hygiene. Severely depressed patients may be totally out of touch with reality and completely unresponsive to anyone else's presence. In such instances the health care provider may be able to do little more than demonstrate caring and empathy by remaining with the patient.

Consistency of care is helpful to depressed patients. They know what to expect, and thus are not repeatedly disappointed when their expectations are not met. An example is consistency in scheduling and carrying out treatments and routine care at the same time each day. A supportive family and interested friends should be involved in choosing and planning activities that are helpful.

Constant vigilance must be maintained to prevent the profoundly depressed patient from injuring himself or committing suicide. Self-destructive behavior is a manifestation of the patient's feeling of worthlessness and loss of self esteem. An awareness of the potential dangers in such a situation should help the provider plan and provide a safe and congenial atmosphere, remaining alert to the early signs of a patient's intention to harm or destroy himself. In most cases suicide is most likely to occur when the patient is recovering from severe depression.
agitated depression major depressive disorder characterized by signs and symptoms of agitation, such as restlessness, racing thoughts, pacing, hand-wringing, sighing, or moaning.
congenital chondrosternal depression a congenital, deep, funnel-shaped depression in the anterior chest wall.
endogenous depression a type of depression caused by somatic or biological factors rather than environmental influences, in contrast to a reactive depression. It is often identified with a specific symptom complex—psychomotor retardation, early morning awakening, weight loss, excessive guilt, and lack of reactivity to the environment—that is roughly equivalent to the symptoms of major depressive disorder.
major depression major depressive disorder.
neurotic depression one that is not a psychotic depression. The term is now little used but has been used sometimes broadly to indicate any depression without psychotic features and sometimes more narrowly to denote only milder forms of depression (dysthymic disorder).
postpartum depression moderate to severe depression beginning slowly and sometimes undetectably during the second to third week post partum, increasing steadily for weeks to months and usually resolving spontaneously within a year. Somatic complaints such as fatigue are common. It is intermediate in severity between the mood fluctuations experienced by the majority of new mothers and frank postpartum psychosis.
psychotic depression strictly, major depressive disorder with psychotic features, such as hallucinations, delusions, mutism, or stupor. The term is often used more broadly to cover all severe depressions causing gross impairment of social or occupational functioning.
reactive depression a usually transient depression that is precipitated by a stressful life event or other environmental factor, in contrast to an endogenous depression.
retarded depression major depressive disorder characterized by signs and symptoms of psychomotor retardation, such as burdened movements and slowed, toneless speech.
situational depression reactive depression.
unipolar depression a type that is not accompanied by episodes of mania or hypomania, such as major depressive disorder or dysthymic disorder. The term is sometimes used more specifically as a synonym of major depressive disorder.

cyclosporine ophthalmic emulsion

Restasis, Sandimmun (UK)CNS: tremor, headache, confusion, paresthesia, insomnia, anxiety, depression, lethargy, weakness

Pharmacologic class: Polypeptide antibiotic

Therapeutic class: Immunosuppressant

Pregnancy risk category C

Respiratory: cough, dyspnea, Pneumocystis jiroveci pneumonia, bronchospasm

FDA Box Warning

• Drug should be prescribed only by physicians experienced in managing systemic immunosuppressive therapy for indicated disease. At doses used for solid-organ transplantation, it should be prescribed only by physicians experienced in immunosuppressive therapy and management of organ transplant recipients. Patient should be managed in facility with adequate laboratory and medical resources. Physician responsible for maintenance therapy should have complete information needed for patient follow-up.

• Neoral may increase susceptibility to infection and neoplasia. In kidney, liver, and heart transplant patients, drug may be given with other immunosuppressants.

• Sandimmune should be given with adrenal corticosteroids but not other immunosuppressants. In transplant patients, increased susceptibility to infection and development of lymphoma and other neoplasms may result from increased immunosuppression.

• Sandimmune and Neoral aren't bioequivalent. Don't use interchangeably without physician supervision.

• In patients receiving Sandimmune soft-gelatin capsules and oral solution, monitor at repeated intervals (due to erratic absorption).


Unclear. Thought to act by specific, reversible inhibition of immunocompetent lymphocytes in G0-G1 phase of cell cycle. Preferentially inhibits T lymphocytes; also inhibits lymphokine production. Ophthalmic action is unknown.


Capsules: 25 mg, 100 mg

Injection: 50 mg/ml

Oral solution: 100 mg/ml

Solution (ophthalmic): 0.05% (0.4 ml in 0.9 ml single-use vial)

Indications and dosages


Adults:Neoral only-1.25 mg/kg P.O. b.i.d. for 4 weeks. Based on patient response, may increase by 0.5 mg/kg/day once q 2 weeks, to a maximum dosage of 4 mg/kg/day.

Severe active rheumatoid arthritis

Adults:Neoral only-1.25 mg/kg P.O. b.i.d. May adjust dosage by 0.5 to 0.75 mg/kg/day after 8 weeks and again after 12 weeks, to a maximum dosage of 4 mg/kg/day. If no response occurs after 16 weeks, discontinue therapy. Gengraf only-2.5 mg/kg P.O. daily given in two divided doses; after 8 weeks, may increase to a maximum dosage of 4 mg/kg/day.

To prevent organ rejection in kidney, liver, or heart transplantation

Adults and children:Sandimmune only-Initially, 15 mg/kg P.O. 4 to 12 hours before transplantation, then daily for 1 to 2 weeks postoperatively. Reduce dosage by 5% weekly to a maintenance level of 5 to 10 mg/kg/day. Or 5 to 6 mg/kg I.V. as a continuous infusion 4 to 12 hours before transplantation.

To increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca

Adults: 1 drop in each eye b.i.d. given 12 hours apart

Off-label uses

• Aplastic anemia
• Atopic dermatitis


• Hypersensitivity to drug and any ophthalmic components
• Rheumatoid arthritis, psoriasis in patients with abnormal renal function, uncontrolled hypertension, cancer (Gengraf, Neoral)
• Active ocular infections (ophthalmic use)


Use cautiously in:
• hepatic impairment, renal dysfunction, active infection, hypertension
• herpes keratitis (ophthalmic use)
• pregnant or breastfeeding patients
• children younger than age 16 (safety and efficacy not established for ophthalmic use).


• For I.V. infusion, dilute as ordered with dextrose 5% in water or 0.9% normal saline solution. Administer over 2 to 6 hours.
• Mix Neoral solution with orange juice or apple juice to improve its taste.
• Dilute Sandimmune oral solution with milk, chocolate milk, or orange juice. Be aware that grapefruit and grapefruit juice affect drug metabolism.
• In postoperative patients, switch to P.O. dosage as tolerance allows.
• Be aware that Sandimmune and Neoral aren't bioequivalent. Don't use interchangeably.
• Before administering eyedrops, invert unit-dose vial a few times to obtain a uniform, white, opaque emulsion.
• Know that eyedrops can be used concomitantly with artificial tears, allowing a 15-minute interval between products.

Adverse reactions

CNS: tremor, headache, confusion, paresthesia, insomnia, anxiety, depression, lethargy, weakness

CV: hypertension, chest pain, myocardial infarction

EENT: visual disturbances, hearing loss, tinnitus, rhinitis; (with ophthalmic use) ocular burning, conjunctival hyperemia, discharge, epiphora, eye pain, foreign body sensation, itching, stinging, blurring

GI: nausea, vomiting, diarrhea, constipation, abdominal discomfort, gastritis, peptic ulcer, mouth sores, difficulty swallowing, anorexia, upper GI bleeding, pancreatitis

GU: gynecomastia, hematuria, nephrotoxicity, renal dysfunction, glomerular capillary thrombosis Hematologic: anemia, leukopenia, thrombocytopenia

Metabolic: hyperglycemia, hypomagnesemia, hyperuricemia, hyperkalemia, metabolic acidosis

Musculoskeletal: muscle and joint pain

Respiratory: cough, dyspnea, Pneumocystis jiroveci pneumonia, bronchospasm

Skin: acne, hirsutism, brittle fingernails, hair breakage, night sweats

Other: gum hyperplasia, flulike symptoms, edema, fever, weight loss, hiccups, anaphylaxis


The following interactions pertain to oral and I.V. routes only.

Drug-drug.Acyclovir, aminoglycosides, amphotericin B, cimetidine, diclofenac, gentamicin, ketoconazole, melphalan, naproxen, ranitidine, sulindac, sulfamethoxazole, tacrolimus, tobramycin, trimethoprim, vancomycin: increased risk of nephrotoxicity

Allopurinol, amiodarone, bromocriptine, clarithromycin, colchicine, danazol, diltiazem, erythromycin, fluconazole, imipenem and cilastatin, itraconazole, ketoconazole, methylprednisolone, nicardipine, prednisolone, quinupristin/dalfopristin, verapamil: increased cyclosporine blood level

Azathioprine, corticosteroids, cyclophosphamide: increased immunosuppression Carbamazepine, isoniazid, nafcillin, octreotide, orlistat, phenobarbital, phenytoin, rifabutin, rifampin, ticlopidine: decreased cyclosporine blood level

Digoxin: decreased digoxin clearance

Live-virus vaccines: decreased antibody response to vaccine

Lovastatin: decreased lovastatin clearance, increased risk of myopathy and rhabdomyolysis

Potassium-sparing diuretics: increased risk of hyperkalemia

Drug-diagnostic tests.Alanine aminotransferase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, glucose, low-density lipoproteins: increased levels

Hemoglobin, platelets, white blood cells: decreased values

Drug-food.Grapefruit, grapefruit juice: decreased cyclosporine metabolism, increased cyclosporine blood level

High-fat diet: decreased drug absorption (Neoral)

Drug-herbs.Alfalfa sprouts, astragalus, echinacea, licorice: interference with immunosuppressant action St. John's wort: reduced cyclosporine blood level, possibly leading to organ rejection

Patient monitoring

• Observe patient for first 30 to 60 minutes of infusion. Monitor frequently thereafter.
• Monitor cyclosporine blood level, electrolyte levels, and liver and kidney function test results.
• Assess for signs and symptoms of hyperkalemia in patients receiving concurrent potassium-sparing diuretic.

Patient teaching

• Advise patient to dilute Neoral oral solution with orange or apple juice (preferably at room temperature) to improve its flavor.
• Instruct patient to use glass container when taking oral solution. Tell him not to let solution stand before drinking, to stir solution well and then drink all at once, and to rinse glass with same liquid and then drink again to ensure that he takes entire dose.
• Tell patient taking Neoral to avoid high-fat meals, grapefruit, and grapefruit juice.
• Advise patient to dilute Sandimmune oral solution with milk, chocolate milk, or orange juice to improve its flavor.
• Instruct patient to invert vial a few times to obtain a uniform, white, opaque emulsion before using eyedrops and to discard vial immediately after use.
• Inform patient that eyedrops can be used with artificial tears but to allow 15-minute interval between products.
• Caution patient not to wear contact lenses because of decreased tear production; however, if contact lenses are used, advise patient to remove them before administering eyedrops and to reinsert 15 minutes after administration.
• Inform patient that he's at increased risk for infection. Caution him to avoid crowds and exposure to illness.
• Instruct patient not to take potassium supplements, herbal products, or dietary supplements without consulting prescriber.
• Tell patient he'll need to undergo repeated laboratory testing during therapy.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, and herbs mentioned above.


(dĕ-presh'ŭn), [TA]
1. Reduction of the level of functioning.
2. Synonym(s): excavation (1)
3. Displacement of a part downward or inward.
4. A mental state or chronic mental disorder characterized by feelings of sadness, loneliness, despair, low self-esteem, and self-reproach; accompanying signs include psychomotor retardation (or less frequently agitation), withdrawal from social contact, and vegetative states such as loss of appetite and insomnia. Synonym(s): dejection (1) , depressive reaction, depressive syndrome
[L. depressio, fr. deprimo, to press down]


/de·pres·sion/ (de-presh´un)
1. a hollow or depressed area; downward or inward displacement.
2. a lowering or decrease of functional activity.
3. a mental state of altered mood characterized by feelings of sadness, despair, and discouragement.depres´sive

agitated depression  major depressive disorder accompanied by more or less constant activity.
anaclitic depression  impairment of an infant's physical, social, and intellectual development resulting from absence of mothering.
congenital chondrosternal depression  congenital deformity with a deep, funnel-shaped depression in the anterior chest wall.
endogenous depression  a type caused by an intrinsic biological or somatic process rather than an environmental influence, in contrast to a reactive depression.
major depression  major depressive disorder.
neurotic depression  one that is not a psychotic depression (q.v.); used sometimes broadly to indicate any depression without psychotic features and sometimes more narrowly to denote only milder forms of depression.
pacchionian depressions  small pits on the internal cranium on either side of the groove for the superior sagittal sinus, occupied by the arachnoid granulations.
psychotic depression  strictly, major depressive disorder with psychotic features, such as hallucinations, delusions, mutism, or stupor; often used more broadly to cover all severe depressions causing gross impairment of social or occupational functioning.
reactive depression , situational depression a usually transient depression that is precipitated by a stressful life event or other environmental factor; cf. endogenous d.
unipolar depression  that unaccompanied by episodes of mania or hypomania, as in major depressive disorder or dysthymic disorder; the term is sometimes used to denote the former specifically.


a. The act of depressing.
b. The condition of being depressed.
2. An area that is sunk below its surroundings; a hollow.
3. The condition of feeling sad or despondent.
4. A mood disorder characterized by persistent sadness or inability to experience pleasure combined with other symptoms including poor concentration, indecisiveness, sleep problems, changes in appetite, and feelings of guilt, helplessness, and hopelessness. Also called clinical depression, major depressive disorder.
5. A lowering or reduction, as:
a. A reduction in physiological vigor or activity: a depression in respiration.
b. A lowering in amount, degree, or position: depression of stock prices.
a. A period of drastic economic decline, characterized by decreasing aggregate output, falling prices, and rising unemployment.
b. A period of widespread poverty and high unemployment.
c. Depression See Great Depression.
7. Meteorology A region of low barometric pressure.
8. The angular distance below the horizontal plane through the point of observation.
9. Astronomy The angular distance of a celestial body below the horizon.


Etymology: L, deprimere, to press down
1 a depressed area, hollow, or fossa.
2 downward or inward displacement.
3 a decrease of vital functional activity.
4 a mood disturbance characterized by feelings of sadness, despair, and discouragement resulting from and normally proportionate to some personal loss or tragedy.
5 an abnormal emotional state characterized by exaggerated feelings of sadness, melancholy, dejection, worthlessness, emptiness, and hopelessness that are inappropriate and out of proportion to reality. The overt manifestations, which are extremely variable, range from a slight lack of motivation and inability to concentrate to severe physiological alterations of body functions and may represent symptoms of a variety of mental and physical conditions, a syndrome of related symptoms associated with a particular disease, or a specific mental illness. The condition is neurotic when the precipitating cause is an intrapsychic conflict or a traumatic situation or event that is identifiable, even though the person is unable to explain the overreaction to it. The condition is psychotic when there is severe physical and mental functional impairment caused by an unidentifiable intrapsychic conflict; it is often accompanied by hallucinations, delusions, and confusion concerning time, place, and identity. Depression may be expressed in a wide spectrum of affective, physiological, cognitive, and behavioral manifestations. The varied behaviors represent the complex actions, reactions, and interactions of the depressed person to stimuli that may be either internal or external. Because the origin of depression can be genetic, pharmacological, endocrinal, infectious, nutritional, neoplastic, or neurological, the behavioral effects can appear as aggression or withdrawal, anorexia or overeating, anger or apathy, or any of myriad responses. Kinds of depression include agitated depression, anaclitic depression, involutional melancholia, major depressive disorder, reactive depression, and retarded depression. See also bipolar disorder. depressive, adj.


Dejection, low spirits Psychiatry A spectrum of affective disorders characterized by attenuation of mood, accompanied by psychogenic pain, diminution of self-esteem, retardation of thought processes, psychomotor sluggishness, disturbances of sleep and appetite, and not uncommonly, suicidal ideation; depression can be triggered by stressful life events, associated with medical or mental disorders, or may be idiopathic Clinical Apathy, anorexia, lack of emotion–flat affect, social withdrawal, fatigue Types Major depression, dysthymia, bipolar disorder; depression may run in families. See Anaclitic depression, Bipolar disorder, Clinical depression, DART, Depressive disorders, Double depression, Endogenous depression, Inbreeding depression, Major depression, Masked depression, Postoperative depression, Postpartum depression, Reactive depression.
Atypical depression A term retired from the DSM, which some clinicians NEJM 1991; 325: 633 use to refer to combinations of mood reactivity, including anhedonia, overeating, oversleeping, chronic poor self-esteem; those with AD are thought to have a better response to MAOIs
Major depressive disorder-recurrent A condition defined as
A. 2 or more major depressive episodes–MDE, which is defined as ≥ 5 of the following present during the same 2-week period, and represent a change from previous functioning and at least one of the 5 is either
1. depressed mood or.
2. loss of interest
 1. Depressed mood most of the day, nearly every day, as indicated either subjectively–self or by observation of others–eg, tearfulness or in children irritability
 2. Marked decreased interest or pleasure in all or most activities for most of the day, nearly every day for the defining period
3. Significant–≥5%, unintentional weight loss or weight gain or loss of appetite
4. Insomnia or hypersomnia nearly every day
5. Psychomotor agitation or retardation nearly every day
6. Fatigue or loss of energy nearly every day
7. Feelings of worthlessness or excessive or inappropriate guilt nearly every day
8. Decreased ability to concentrate or think nearly every day
9. Recurrent thoughts of death, recurrent suicidal ideation and/or suicidal plans
B. The MDE is not better explained for by schizoaffective disorder, or is not superimposed on schizophrenia, schizophreniform disorder, delusional disorder, or psychotic disorder NOS
C. There has never been a manic episode or hypomanic episode
Melancholic depression Endogenous depression Characterized by pervasive sadness, hopelessness, loss of interest in activities, and physical symptoms, eg weight loss, sleep problems; in MD, there may be an ↑ 'threshold' that requires little external input to initiate recurrence
Reactive depression–an excess response to stressful life events


(dĕ-presh'ŭn) [TA]
1. Reduction of the level of functioning.
2. A hollow or sunken area.
3. Displacement of a part downward or inward.
4. A temporary mental state or chronic mental disorder characterized by feelings of sadness, loneliness, despair, low self-esteem, and self-reproach; accompanying signs include psychomotor retardation or less frequently agitation, withdrawal from social contact, and vegetative states such as loss of appetite and insomnia.
Synonym(s): dejection.


Sadness or unhappiness, usually persistent. This may be a normal reaction to unpleasant events or environment or may be the result of a genuine depressive illness. Pathological depression features a sense of hopelessness, dejection and fear out of all proportion to any external cause. There is persistent low mood, loss of interest or pleasure, low energy, fatigue, disturbed sleep, slowing down of body and mind, poor concentration, confusion, self-reproach, self-accusation and loss of self-esteem. Suicide is an ever-present risk. NICE guidelines for treatment recommend fluoxetine or citalopram. Exercise is valuable.


A state of being depressed marked especially by sadness, inactivity, difficulty with thinking and concentration, a significant increase or decrease in appetite and time spent sleeping, feelings of dejection and hopelessness, and sometimes suicidal thoughts or an attempt to commit suicide.


a mood disorder characterized by feelings of profound sadness. May be classified by severity, by the presence of somatic symptoms and by the presence or absence of psychotic symptoms. Cognitive symptoms include hopelessness, helplessness, guilt, low self-esteem and suicidal thoughts. endogenous depression not resulting from a reaction to a particular negative experience. reactive depression resulting from a reaction to a particular negative experience (such as bereavement, physical illness or loss of employment), also known as exogenous depression. Research has shown that a structured exercise programme can have a mood-enhancing effect similar (and complementary) to that seen with the use of antidepressant medication. See also antidepressants.


n a condition identified by loss of energy and ability or desire to function, poor sleep or appetite, and/or exaggerated feelings of hopelessness and discouragement.


Downward rotation of an eye. It is accomplished by the inferior rectus and superior oblique muscles. It can be induced by using base-up prisms. Syn. infraduction; deorsumduction.


(dĕ-presh'ŭn) [TA]
1. Opening or indentation on an oral cavity surface.
2. Reduction of the level of functioning.

depression (dēpresh´ən),

n 1. a decrease of functional activity.
n 2. a pitted area on a tooth or other anatomic surface.
depression, developmental,
n depression seen in a defined region on a tooth.
depression, mandible,
n the lowering of the mandible caused by rotational movement of the temporomandibular joint.
depression, postpartum,
n a moderate to severe form of depression that occurs in women beginning approximately 2 to 3 weeks after childbirth as a result of physical and psychologic factors. Symptoms include fatigue, loss of appetite, and lack of enthusiasm for everyday activities.
depression, psychologic,
n a clinical syndrome of neurotic or psychotic proportions, consisting of lowering of mood tone (feelings of painful dejection), difficulty in thinking, and psychomotor retardation. As commonly used, depression ordinarily refers only to the mood element, which would be more appropriately labeled dejection, sadness, gloominess, despair, or despondency. Many such patients lack motivation and concern for their oral health or dental needs.


1. a hollow or depressed area.
2. a lowering or decrease of functional activity.
3. decreased interest in surroundings, decreased response to external stimuli. The least degree in a range of depressive mental states. See also somnolence, lassitude, narcolepsy, catalepsy, syncope, coma.

depression fracture
important in the skull where they may penetrate brain tissue, introduce infection, or cause pressure on the brain because of hemorrhage or hematoma formation.

Patient discussion about depression

Q. am i depressed i feel sad,lonely,streeted,worthless that nothing matter anymore..i sleep all the time,loss of intrest of everything..

A. yes,go see a dr. a.s.a.p.,i went through a bad depression mode during the divorce of my first wife,i slept for 3 days,no food,no shower,nobody to talk to,so i finlly went to the dr. he put me on prozac,and after a few days i was back to my old self again,JUST GO SEE A DR.

Q. what about depression?

A. Hey. It might be nice "for you" if you came back to this and said some more, or read some of the other questions and answers.

Q. what causes depression?

A. You need to define what you mean by depression. Clincal depression is one thing and feeling low from time to time is another. There is a lot of good information at your finger tips on the www. You may want to shy away from those websites that are paid for my the pharmacutical companies. They want to sell you their drugs. What is the cause of your depression? Are there one or two things that you can point to? If you are clinically depressed, see a dr., that is, if you can get out of bed...If you are depressed due to family, or the fools in Washington, those are things that you may work out with your minister or rabbi or a therapist. I have found a lot of good information on therapy and therapists on
You may want to start there.

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