congenic


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Related to congenic: backcrossing

con·gen·ic

(kon-jen'ik),
Relating to an inbred strain of animals produced by repeated crossing of one gene line onto another inbred (isogenic) line.
[con- + G. genos, birth, + -ic]

congenic

/con·gen·ic/ (kon-jen´ik) of or relating to a strain of animals developed from an inbred (isogenic) strain by repeated matings with animals from another stock that have a foreign gene, the final congenic strain then presumably differing from the original inbred strain by the presence of this gene.
Referring to organisms which differ in only one gene locus, the result of specific inbreeding of animals in experimental settings

congenic

Of organisms that differ only at a single genetic locus.

congenic

a genetic term usually used to refer to specially inbred strains of mice that differ only in restricted regions of the genome; used particularly in mapping major histocompatibility complex antigens.
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References in periodicals archive ?
A congenic inbred strain produced mice identical in genetic background except for the single gene substitution at the microphthalmic locus.
were combined in a 1:1 ratio and transferred into unexposed congenic recipients (CD90.
Further, MPDZ congenic mice, which possess the QTL interval containing Mpdz from the C57BL/6J strain in a genetic background that is more than 99 percent DBA/2J DNA, demonstrate less severe ethanol withdrawal (Fehr et al.
METHODS: We used two congenic mouse models that differ at the Ahr gene and encode AHRs with a 10-fold difference in signaling activity.
Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a < 1 cendmorgan interval of murine chromosome 4: Identification of Mpdz as a candidate gene.
Previous studies have shown that analysis of inbred lines, their crosses, congenic lines and noninbred populations has revealed the anti-RSV response of many B complex haplotypes (Bacon et al.
KEY WORDS: Genetic theory of alcohol and other drug use; genetics and heredity; behavioral phenotypes, genetic trait, quantitative traits; quantitative trait locus (QTL), QTL mapping; congenics; interval-specific congenics (ISCs); congenic strains; animal models
Congenic animals (strains): Animal strains generated in the laboratory by mating two inbred strains, and backcrossing the descendants for 5-10 generations with one of the original strains (i.
2002), and age-related, sexually dimorphic obesity has not been observed in congenic PPAR[alpha]-null mice (Akiyama et al.
Effect of Hoodia plant on weight loss in congenic obese LA/Ntul//-cp rats.
The strain's fertility was investigated, according to Kwon-Chung (7), by crossing the isolate with reference serotype A strains H99 (MAT[alpha]) and IUM 96-2828 (MATa), and with serotype D congenic strains JEC20 (MATa) and JEC21 (MAT[alpha]).
Acetylator genotype-dependent N-acetylation of arylamines in vivo and in vitro by hepatic and extrahepatic organ cytosols of Syrian hamsters congenic at the polymorphic acetyltransferase locus.