congenic


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to congenic: backcrossing

con·gen·ic

(kon-jen'ik),
Relating to an inbred strain of animals produced by repeated crossing of one gene line onto another inbred (isogenic) line.
[con- + G. genos, birth, + -ic]

congenic

/con·gen·ic/ (kon-jen´ik) of or relating to a strain of animals developed from an inbred (isogenic) strain by repeated matings with animals from another stock that have a foreign gene, the final congenic strain then presumably differing from the original inbred strain by the presence of this gene.
Referring to organisms which differ in only one gene locus, the result of specific inbreeding of animals in experimental settings

congenic

Of organisms that differ only at a single genetic locus.

congenic

a genetic term usually used to refer to specially inbred strains of mice that differ only in restricted regions of the genome; used particularly in mapping major histocompatibility complex antigens.
Mentioned in ?
References in periodicals archive ?
Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat: congenic analysis," Hypertension, vol.
Soliman (1975) examined 20 of the congenic blue lines for mitotic chromosome number.
A congenic inbred strain produced mice identical in genetic background except for the single gene substitution at the microphthalmic locus.
Estimates have been made of how much heterozygosity remains in congenic strains, depending on the number of backcrosses used to produce them.
The AcB/BcA recombinant congenic strains of mice: strategies for phenotype dissection, mapping and cloning of quantitative trait genes (Anny Fortin, Eduardo Diez, Janet E.
Moreover, AhR-mediated regulation of body weight may result from the combined effects of activation of AhR in various cell types because congenic mice with high AhR signaling activity were more susceptible to diet-induced obesity compared with those with low AhR activity (Kerley-Hamilton et al.
Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection.
0/0] congenic lines by backcrossing to FVB/N mice for 10 generations, followed by genetic testing (Charles River UK, Ltd.
Positional cloning using novel interval-specific congenic mouse strains (1) narrowed this QTL to a 1.
1991) Bone marrow-thymus interactions during thymic lymphomagenesis induced by fractionated radiation exposure in B10 mice: Analysis using bone marrow transplantation between Thy 1 congenic mice.
They address controversies surrounding the use of animal models and new methods of discovery for questions of pathogenesis and therapy, such as in silico; humanized, transgenic, or congenic models; viral, antigen, or cell-induced models, and complications.
Role of inorganic nitrogen oxides and tumor necrosis factor alpha in killing Leishmania donovani amastigotes in gamma interferon-lipopolysaccharide-activated macrophages from Lshs and Lshr congenic mouse strains.