conformation

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con·for·ma·tion

(kon'fōr-mā'shŭn),
The spatial arrangement of a molecule achieved by rotation of groups about single covalent bonds, without breaking any covalent bonds; the latter restriction differentiates conformation from configuration (as in anomers and related stereoisomers) where a bond or bonds must be broken in going from one form (configuration) to another. Conformation is one of the most important aspects of sugar chemistry and is basic to an understanding of the chemical properties of sugars. Compare: configuration.

con·for·ma·tion

(kon'fōr-mā'shŭn)
The spatial arrangement of a molecule achieved by rotation of groups about single covalent bonds, without breaking any covalent bonds.
Compare: configuration

conformation

(kŏn″for-mā′shŭn)
The form or shape of a part, body, material, or molecule.

conformation

symmetry, size and shape of the various body regions relative to each other or the general appearance of the animal in terms of satisfying the observer's appreciation of what is a desirable appearance. Most breed societies issue lists of desirable and undesirable points of conformation. Most of them are desirable. Some are not and react adversely on the animals' well-being. Desirable conformation may also be indicated by diagrams or photographs.
Also may refer to the spatial arrangement of atoms in a molecule.

mitochondrial conformation
mitochondria may be in an abnormal state of condensed conformation, detected by comparison with mitochondria of orthodox status; orthodox conformation is linked to inactive oxidase phosphorylation, condensed to active phosphorylation.
References in periodicals archive ?
29 /PRNewswire/ -- Adlyfe, a private company developing novel diagnostic testing technologies for early targets of amyloid diseases, announced today the publication of a study, "Detection of misfolded prion protein in blood with conformationally sensitive peptides," in the August 2007 issue of the journal Transfusion.
A common feature of all such glutamate agonists which bind to these receptors is that a portion of their structure represents a conformationally restricted form of glutamic acid, and so differences in efficacy of binding to the receptor, and hence potency, can be attributed to differences in the chemistry of the side-chain.
Recently, boron functionalised vicinal dioxime complexes (gated glyoximes) have provided conformationally switchable metallocyclophane hosts in which non-bonded interactions (coulombic, charge transfer, H-bonding, dipolar forces) between the bound axial substrate and the macrocycle superstructure may be studied in detail.
Conformationally constrained tricyclic HIV integrase inhibitors
The title compound is needed as a precursor in the synthesis of conformationally constrained analogues of the antimalarial compound mefloquine.
It is likely that antibodies raised against the zymogen can have different reactivities toward proCPU, proCPU bound to plasminogen, CPU, and conformationally and proteolytically inactivated forms of proCPU and CPU (23, 24, 31).
The conformationally insensitive N-H stretching mode cannot be separated into crystalline and amorphous hydrogen-bonded phases [42].
soluble Abeta, conformationally modified forms, Abeta fibrils, plaque); the selective targeting of the N-terminal or C-terminal ends of Abeta; and delivery and transport across the blood brain barrier.
Conan MB, a conformationally sensitive antibody, was first used as a capture antibody for CK-MB, followed by CK activity measurement (17).
Whereas chiral monomers with asymmetric carbon atoms have been widely used and their chiral copolymers have been studied (6-8), chiral monomers based on atropisomerism (chirality originating from hindered rotation about single bonds which leads to two conformationally stable optical antipodes) have not yet been used in order to obtain chiral copolymers.
Danho joins Enteris as one of the foremost leaders in the discovery of peptide-based drugs, peptide mimetics, and conformationally restricted peptides.