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conformational disease

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conformational disease,
a general term for a number of disorders, such as Alzheimer's disease and Pick's disease, caused by mutations in the structure of specific proteins, leading to the aggregation and deposition of abnormal proteins.


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They have found a process by which proteins with a tendency to cause conformational diseases such as amyotrophic lateral sclerosis, familial amyloidotic polyneuropathy, familial amyloidotic cardiomyopathy, etc.
Conformational diseases such as those in Table 1 are associated with proteins that do not attain or maintain their native structure resulting in aggregation and insolubilization [36,37].
In recent years our understanding of the nature of spontaneous protein aggregation has increased greatly because of its importance in the pathogenesis of conformational diseases such as amyloidosis, Alzheimer's disease and the spongieform encephalopathies.
 
 
 
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