AC Immune is a privately held company focusing on the development of therapies against Alzheimer's disease, a so-called conformational disease
Beta-amyloid constitutes an important target for disease-modification of Alzheimer's disease, a so-called conformational disease
Stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER) is observed in many diseases which are now recognized as protein conformational diseases
, including genetic diseases, neurodegenerative diseases, and retinal degenerative diseases.
The Nature Chemical Biology paper is titled "Small-Molecule Proteostasis Regulators for Protein Conformational Diseases
They have found a process by which proteins with a tendency to cause conformational diseases
such as amyotrophic lateral sclerosis, familial amyloidotic polyneuropathy, familial amyloidotic cardiomyopathy, etc.
Alpha, antitrypsin deficiency--a model for conformational diseases
Alpha1-antitrypsin deficiency--a model for conformational diseases
In recent years our understanding of the nature of spontaneous protein aggregation has increased greatly because of its importance in the pathogenesis of conformational diseases
such as amyloidosis, Alzheimer's disease and the spongieform encephalopathies.
Identification of bistable network topologies associated with toxic aggregation thresholds found in conformational diseases
AC Immune's SupraAntigen(TM) technology has proven potential for conformation-specific immunotherapy of Alzheimer's Disease and opens possibilities for the treatment of other conformational diseases
," said Andreas Muhs.
There is an outstanding market opportunity in Alzheimer's and conformational diseases
, said Martin Velasco, Chairman of the Board of AC Immune.
Alpha-l-antitrypsin deficiency--a model for conformational diseases