conformation

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Related to conformational: Conformational analysis, conformational epitope

con·for·ma·tion

(kon'fōr-mā'shŭn),
The spatial arrangement of a molecule achieved by rotation of groups about single covalent bonds, without breaking any covalent bonds; the latter restriction differentiates conformation from configuration (as in anomers and related stereoisomers) where a bond or bonds must be broken in going from one form (configuration) to another. Conformation is one of the most important aspects of sugar chemistry and is basic to an understanding of the chemical properties of sugars. Compare: configuration.

con·for·ma·tion

(kon'fōr-mā'shŭn)
The spatial arrangement of a molecule achieved by rotation of groups about single covalent bonds, without breaking any covalent bonds.
Compare: configuration

conformation

(kŏn″for-mā′shŭn)
The form or shape of a part, body, material, or molecule.

conformation

symmetry, size and shape of the various body regions relative to each other or the general appearance of the animal in terms of satisfying the observer's appreciation of what is a desirable appearance. Most breed societies issue lists of desirable and undesirable points of conformation. Most of them are desirable. Some are not and react adversely on the animals' well-being. Desirable conformation may also be indicated by diagrams or photographs.
Also may refer to the spatial arrangement of atoms in a molecule.

mitochondrial conformation
mitochondria may be in an abnormal state of condensed conformation, detected by comparison with mitochondria of orthodox status; orthodox conformation is linked to inactive oxidase phosphorylation, condensed to active phosphorylation.
References in periodicals archive ?
For example, to understand enzyme specificity, students need to simultaneously learn that binding of a substrate to its enzyme drives the latter to undergo a proper conformational change necessary to align the various catalytic amino acid residues in the active site along with the appropriate reactive groups of this substrate.
The differences might be influenced by both amino acid compositions and conformational structures.
During 2009-2010, we analyzed conformational stability of [PrP.
In the present work, they elucidate that the chiral phosphorus atoms in the polymer coordinate to transition metals such as palladium, resulting in the conformational change of the polymer and chiral transfer from P-stereogenic phosphine units to rigid conjugated linkers in the polymer backbone.
It is known that conformational alterations of proteins result in increasing the numbers of exosed epitopes and this was attempted with the cyst antigens.
Kliger stated, "Our goal was to design peptides that have the capability to block conformational changes within a target protein, thereby modulating its activity.
Statin incubation was shown to induce conformational changes in the CD20 target and impaired the binding of ofatumumab and rituximab to the CD20 molecule.
The gp120 binds to CD4, which induces a conformational change, exposing a region that then binds to a chemokine receptor on the T cell.
We'll look at fluorescent signals and see how they change related to this fusion-pore opening," says Lindau, "to give us an idea if there are conformational changes happening.
The maximum stimulation of rubber biosynthetic rate appears to be the result of a conformational change that greatly increases the binding affinity of the enzyme for the monomer, an effect most pronounced in H.
To distinguish the linear from the conformational epitopes of the SARS-CoV N protein, yeast cells were heated to 80[degrees]C for 30 min in a thermostatically controlled water bath and then chilled on ice 20 min before labeling with antibodies (30).
An increase in polymer concentration leads to a rise in the isotherm as a result of a nonstoichiometric adsorption, which can be attributed to conformational changes from a flat form of the polymer to a loops and tails form.