conformation

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con·for·ma·tion

(kon'fōr-mā'shŭn),
The spatial arrangement of a molecule achieved by rotation of groups about single covalent bonds, without breaking any covalent bonds; the latter restriction differentiates conformation from configuration (as in anomers and related stereoisomers) where a bond or bonds must be broken in going from one form (configuration) to another. Conformation is one of the most important aspects of sugar chemistry and is basic to an understanding of the chemical properties of sugars. Compare: configuration.

con·for·ma·tion

(kon'fōr-mā'shŭn)
The spatial arrangement of a molecule achieved by rotation of groups about single covalent bonds, without breaking any covalent bonds.
Compare: configuration

conformation

(kŏn″for-mā′shŭn)
The form or shape of a part, body, material, or molecule.

conformation

symmetry, size and shape of the various body regions relative to each other or the general appearance of the animal in terms of satisfying the observer's appreciation of what is a desirable appearance. Most breed societies issue lists of desirable and undesirable points of conformation. Most of them are desirable. Some are not and react adversely on the animals' well-being. Desirable conformation may also be indicated by diagrams or photographs.
Also may refer to the spatial arrangement of atoms in a molecule.

mitochondrial conformation
mitochondria may be in an abnormal state of condensed conformation, detected by comparison with mitochondria of orthodox status; orthodox conformation is linked to inactive oxidase phosphorylation, condensed to active phosphorylation.
References in periodicals archive ?
10) The chemical shift change of the other residues could be ascribed to conformational changes induced by nucleotide binding.
Hunter, Institute for Animal Health, Edinburgh, Scotland) and CH1641-like isolates showed conformational stabilities close to classical scrapie, with GdnH[Cl.
Thus, the characterization of this helix and the affect on function provides further evidence for a role in global conformational stability.
Depolarization of nerve axon membranes induces conformational changes in sodium channel molecules which then open, allowing the flow of inward current that underlies the propagated nerve impulse.
A disulfide cross-link was introduced between residues 22 and 87 in [DELTA]75-83 subtilisin to probe the conformational entropy of the transition state for folding (39).
In addition to its role in movement and synthesis, ATP energy can be used to induce irreversible conformational changes in protein molecules.
However, this concept may represent a novel approach for the rational design of drugs that may prevent protein conformational changes implicated in a variety of diseases.
CMRS has proved to be a useful tool for finding out about quantitative conformational changes in polymeric materials.
These systems include structural glasses and supercooled liquids, polymers, complex liquids, protein conformational dynamics, and strongly interacting electron systems with quenched/self-generated disorder.
Further improvements in single molecule imaging have been made with computer image analysis that tracks molecular position with nanometer and millisecond accuracy (14),(15) and with fluorescence spectroscopic techniques such as fluorescence resonance energy transfer (FRET) (16),(17) or orientation by polarization (18), (19) to determine the conformational changes of biomolecules.
Near-field coupling between metal nanoparticles is extremely sensitive to nanometer conformational changes.