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conduction pathway |
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conduction pathway, the route followed by nerve impulses propagated along synaptically connected neurons. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Despite the diversity of structural folds within the subfamily, it was suggested that these peptides share common key elements: The functional dyad, which contains a positively charged residue whose side chain plugs the conduction pathway separated by -6-7 [Angstrom] from a hydrophobic group; and a ring of basic amino-acid residues which contribute to a multipoint interaction of the toxin and channel (1). In an AV nodal ablation procedure, part of the conduction pathway in the heart is removed, which effectively prevents the impulses from the upper chamber from reaching the lower chamber. The structure of the ion conduction pathway is remarkably conserved in these channels and consists of four subunits symmetrically placed around the channel axis. |
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