concanavalin


Also found in: Dictionary, Wikipedia.

concanavalin

 [kon″kah-nav´ah-lin]
a lectin isolated from the jack bean (Canavalia ensiformis) that agglutinates mammalian erythrocytes and is a mitogen that stimulates predominantly T lymphocytes. Abbreviated ConA.

concanavalin

either of two phytohemagglutinins isolated along with canavalin from the meal of the jack bean (Canavalia ensiformis and other species of Canavalia), which agglutinate the blood of mammals as a result of reaction with polyglucosans.

concanavalin A
binds to sugar residues on cell surfaces and stimulates T lymphocytes to proliferate; has also been shown to inhibit the growth of ascites tumors. Called also Con A.
References in periodicals archive ?
Thirty microliter aliquots of the equilibrated cells were then preincubated in polypropylene tubes at 37[degrees]C in the presence of the test compounds (hydroxytyrosol or oleuropein), before incubation with concanavalin A (final concentration 200 [micro]g/ml, with 50 [micro]g/ml phosphatidylserine added as a co-stimulator), compound 48/80 (final concentration 10 [micro]g/ml), or calcium ionophore A23187 (final concentration 50 [micro]g/ml), for 10 min at 37[degrees]C.
Orally administration of 25 to 100 mg sodium nitrite per kg diet to Balb/c mice for 21 d has resulted in a dose dependent decrease of lymphocyte percentages, concanavalin A and lipopolysaccharide-induced lymphocyte proliferation, natural killer cell activity against WEHI-164 target cells, as well as IgM and IgG titers against injected sheep erythrocytes (Chow and Hong, 2002).
Astilbin also prevented concanavalin A-induced liver injury by reducing tumor necrosis factor-[alpha] (TNF-[alpha]) production and T lymphocyte adhesion (9), and it significantly suppressed collagen-induced arthritis by causing the dysfunction of lymphocytes and inhibiting lymphocyte migration (10, 11).
Murine splenocytes placed in serum-free medium will be stimulated with concanavalin A with or without phorbol 12-myristate 13-acetate (PMA).
Considering the application of the compounds in chemopreventive medicine, we examined their effects on normal human peripheral blood lymphocytes (PBLs) stimulated with concanavalin A (Con-A) all compounds exhibited no marked growth inhibition at lower doses than 150p,M.
Lymphocyte mitogen concanavalin A (Type IV, C-2010, Sigma St Louis, MO, USA) was added at a final concentration of 16 mg/ml of culture medium, after which the plates were incubated at 37[degrees]C in an incubator in an atmosphere of 5% C[O.
We previously developed a multilectin affinity system for efficient and specific enrichment of human serum glycoproteins (7) and demonstrated that a multilectin affinity chromatography (M-LAC) [4] column containing Jacalin, concanavalin A, and wheat germ agglutinin could overcome the low affinity and lack of complete glycoprotein capture that typically occurs with a single-lectin affinity selector.
In some cases plant lectins have been shown to be able to act as opsonins in invertebrate phagocyte systems, and concanavalin A receptors have been described on oyster hemocytes (Sami et al.
The cytochrome P450 aromatase was purified from equine microsomes, after its separation from reductase, by successive chromatographic steps: concanavalin A-Sepharose 4B affinity column, diethyl amino ethyl-Sepharose CL-6B ion exchange, and hydroxyapatite-Sepharose 4B adsorption/partition columns (Moslemi et al.
The mitogen, lipopolysaccharide (LPS, Sigma, USA) or concanavalin A (ConA, Sigma, USA), was added at a final concentration of 10 [micro]g/ml.
A mitogen called Concanavalin A (ConA, Sigma, Israel) was used to stimulate the proliferation of the T-cells.