compound analgesics

compound analgesics

lower-potency opioid analgesics (e.g. codeine, dihydrocodeine, dextropropoxyphene) combined with paracetamol, creating an analgesic effect more potent than either drug alone (Table 1)
Table 1: Analgesic codeine preparations
AgentConstituents
Co-codamol(8/500) 8 mg codeine phosphate; 500 mg paracetamol
(15/500) 15 mg codeine phosphate; 500 mg paracetamol
(30/500) 30 mg codeine phosphate; 500 mg paracetamol
Co-dydramol(10/500) 10 mg dihydrocodeine tartrate; 500 mg paracetamol
Co-proxamol(32.5/325) 32.5 mg dextropropoxyphene hydrochloride; 325 mg paracetamol

Note: co-proxamol withdrawn in UK, due to adverse links to heart failure and respiratory depression

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Compound analgesics consisting of phenacetin, aspirin and caffeine became popular and analgesic nephropathy was born.
In 1979 legislation was passed in Queensland confining the sale of compound analgesics to pharmacies.
Compound analgesics were chosen as they reduce the total number of tablets patients need to take.