compound analgesics

compound analgesics

lower-potency opioid analgesics (e.g. codeine, dihydrocodeine, dextropropoxyphene) combined with paracetamol, creating an analgesic effect more potent than either drug alone (Table 1)
Table 1: Analgesic codeine preparations
AgentConstituents
Co-codamol(8/500) 8 mg codeine phosphate; 500 mg paracetamol
(15/500) 15 mg codeine phosphate; 500 mg paracetamol
(30/500) 30 mg codeine phosphate; 500 mg paracetamol
Co-dydramol(10/500) 10 mg dihydrocodeine tartrate; 500 mg paracetamol
Co-proxamol(32.5/325) 32.5 mg dextropropoxyphene hydrochloride; 325 mg paracetamol

Note: co-proxamol withdrawn in UK, due to adverse links to heart failure and respiratory depression

Mentioned in ?